PMID: 11604089Oct 18, 2001Paper

Risk estimation based on chromosomal aberrations induced by radiation

Radiation Research
Marco DuranteF Cucinotta

Abstract

The presence of a causal association between the frequency of chromosomal aberrations in peripheral blood lymphocytes and the risk of cancer has been substantiated recently by epidemiological studies. Cytogenetic analyses of crew members of the Mir Space Station have shown that a significant increase in the frequency of chromosomal aberrations can be detected after flight, and that such an increase is likely to be attributed to the radiation exposure. The risk of cancer can be estimated directly from the yields of chromosomal aberrations, taking into account some aspects of individual susceptibility and other factors unrelated to radiation. However, the use of an appropriate technique for the collection and analysis of chromosomes and the choice of the structural aberrations to be measured are crucial in providing sound results. Based on the fraction of aberrant lymphocytes detected before and after flight, the relative risk after a long-term Mir mission is estimated to be about 1.2-1.3. The new technique of mFISH can provide useful insights into the quantification of risk on an individual basis.

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Citations

Jul 11, 2002·Mutation Research·G ObeM E Drets
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·S M MortazaviA Niroomand-rad
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F Ballarini, A Ottolenghi
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Valentina d'AlesioMarco Salvatore
Oct 4, 2002·Nutrition·Nancy D TurnerJoanne R Lupton
Mar 22, 2002·Mutation Research·Stefano Bonassi, William W Au
Sep 28, 2004·European Journal of Nuclear Medicine and Molecular Imaging·D ViolotC Parmentier
Aug 17, 2004·Radiation and Environmental Biophysics·Francesca Ballarini, Andrea Ottolenghi
Aug 19, 2004·Radiation and Environmental Biophysics·Marco J P BrugmansMargot Tirmarche
Jun 10, 2011·Radiation and Environmental Biophysics·Z Z WangW X Zhao
Feb 28, 2004·Astrobiology·Karine Van DoninckKoen Martens
Nov 27, 2010·Radiation Protection Dosimetry·Y A Eidelman, S G Andreev
Jun 7, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M HortsmannG Obe
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·G GrossiN Matsufuji
Jun 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marco Durante
Nov 10, 2009·International Journal of Radiation Biology·Daniela BeckerClaudia Fournier
Sep 29, 2005·Radiation Research·Francesca Ballarini, Andrea Ottolenghi
Sep 29, 2005·Radiation Research·Marco Durante
Jan 15, 2011·Mutation Research·Megumi HadaFrancis A Cucinotta
Apr 16, 2005·Zeitschrift für medizinische Physik·Marco Durante
Dec 19, 2007·The Journal of the Royal Society for the Promotion of Health·Lekha Sharma
Oct 19, 2002·Radiation Research·M DuranteF A Cucinotta

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