Apr 18, 2015

Risk factor analyses for the return of spontaneous circulation in the asphyxiation cardiac arrest porcine model

Chinese Medical Journal
Cai-Jun WuJun Yang

Abstract

Animal models of asphyxiation cardiac arrest (ACA) are frequently used in basic research to mirror the clinical course of cardiac arrest (CA). The rates of the return of spontaneous circulation (ROSC) in ACA animal models are lower than those from studies that have utilized ventricular fibrillation (VF) animal models. The purpose of this study was to characterize the factors associated with the ROSC in the ACA porcine model. Forty-eight healthy miniature pigs underwent endotracheal tube clamping to induce CA. Once induced, CA was maintained untreated for a period of 8 min. Two minutes following the initiation of cardiopulmonary resuscitation (CPR), defibrillation was attempted until ROSC was achieved or the animal died. To assess the factors associated with ROSC in this CA model, logistic regression analyses were performed to analyze gender, the time of preparation, the amplitude spectrum area (AMSA) from the beginning of CPR and the pH at the beginning of CPR. A receiver-operating characteristic (ROC) curve was used to evaluate the predictive value of AMSA for ROSC. ROSC was only 52.1% successful in this ACA porcine model. The multivariate logistic regression analyses revealed that ROSC significantly depended on the time of pr...Continue Reading

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Mentioned in this Paper

Study
Basic Research
Ventricular Fibrillation
Amsacrine
Infarction, Anterior Cerebral Artery
Transcription Initiation
Logistic Regression
Basic Cardiac Life Support
2-butenal
Evaluation

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