Risk factor analysis for a complicated postoperative course after neonatal arterial switch operation: The role of troponin T

Congenital Heart Disease
Martin ChristmannWalter Knirsch

Abstract

To find risk factors for a complicated early postoperative course after arterial switch operation (ASO) in neonates with d-transposition of the great arteries (dTGA). In addition to anatomical and surgical parameters, the predictive value of early postoperative troponin T (TnT) values in correlation to the early postoperative course after ASO is analyzed. Seventy-nine neonates (57 (72%) male) with simple dTGA treated by ASO between 2009 and 2016 were included in the analysis. A complicated early postoperative course (30 days) was defined by one of the following criteria: (A) moderate to severe cardiac dysfunction without rhythm disturbances, (B) rhythm disturbances causing hemodynamic instability with the need for medical treatment, (C) signs for ischemia in ECG, (D) need for surgical or catheter interventional reinterventions other than diagnostic, or (E) other reasons. Forty of 79 patients (51%) showed a complicated early postoperative course after ASO, with 2 patients dying after 13 and 16 days. Patients with a complicated early postoperative course had a longer PICU stay (P < .001), needed longer mechanical ventilator support (P = .001) and longer inotropic support (P = .03), and more reinterventions (surgical or catheter i...Continue Reading

References

May 20, 1999·Journal of the American College of Cardiology·E D BlumeT Geva
May 20, 1999·Journal of the American College of Cardiology·F F ImmerT Carrel
Sep 28, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J WetterA E Urban
Jan 10, 2002·The Journal of Thoracic and Cardiovascular Surgery·Kathy J JenkinsLisa I Iezzoni
Dec 7, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Edvin PriftiVittorio Vanini
Mar 20, 2003·The Annals of Thoracic Surgery·Hajime ImuraMassimo Caputo
Dec 24, 2003·Circulation·Jart H C DirisMarja P van Dieijen-Visser
May 1, 2004·BMJ : British Medical Journal·Peter AmmannHans Rickli
Oct 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Neeta R SaraiyaJan M Queagebeur
Jul 13, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomaso BottioGiovanni Stellin
Aug 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·George E SarrisUNKNOWN European Congenital Heart Surgeons Association
Oct 26, 2006·The Annals of Thoracic Surgery·Leena H MildhPaula H Rautiainen
Aug 28, 2007·The Annals of Thoracic Surgery·Zuhab A QamarRichard G Ohye
Dec 24, 2010·Pediatric Research·Rajesh KoralkarDavid Askenazi
Nov 23, 2011·Circulation·Vinay S Mahajan, Petr Jarolim
Jan 26, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Karel AllegaertJohn N van den Anker
May 23, 2012·The Annals of Thoracic Surgery·Tyson A FrickeIgor E Konstantinov
Aug 14, 2012·International Journal of Cardiology·Aleksander KempnyGerhard-Paul Diller
Oct 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN Ad-hoc working group of ERBPWim Van Biesen
Nov 21, 2012·Scandinavian Cardiovascular Journal : SCJ·Anneli EerolaJaana I Pihkala
Nov 5, 2013·Journal of the American College of Cardiology·Brett R AndersonEmile A Bacha
Jan 15, 2016·Current Opinion in Pediatrics·Guido FillerAna Catalina Alvarez-Elías
Feb 15, 2017·Clinical Biochemistry·Vincent FridénOla Hammarsten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.