Risk Factor Analysis for Secondary Malignancy in Dexrazoxane-Treated Pediatric Cancer Patients

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Hyery KimHee Young Shin

Abstract

Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies in dexrazoxane-treated pediatric patients. Data was collected from 15 hospitals in Korea. Patients who received any anthracyclines, and completed treatment without stem cell transplantation were included. For efficacy evaluation, the incidence of cardiac events and cardiac event-free survival rates were compared. Data about risk factors of secondary malignancies were collected. Data of total 1,453 cases were analyzed; dexrazoxane with every anthracyclines group (D group, 1,035 patients) and no dexrazoxane group (non-D group, 418 patients). Incidence of the reported cardiac events was not statistically different between two groups; however, the cardiac event-free survival rate of patients with more than 400 mg/m2 of anthracyclines was significantly higher in D group (91.2% vs. 80.1%, p=0.04). The 6-year cumulative incidence of secondary malignancy was not different between both groups after considering follow-up duration difference (non-D, 0.52%±0.37%; D, 0.60%±0.28%; p=0.55). The most in...Continue Reading

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Citations

Aug 22, 2018·Expert Opinion on Drug Safety·Antonis A ManolisAntonis S Manolis
Mar 11, 2020·Cardio-Oncology·Neha BansalSteven E Lipshultz
Feb 23, 2021·Frontiers in Pediatrics·Varen Zhi Zheng TanChing Kit Chen
Apr 30, 2021·Colombia médica : CM·Adriana Linares BallesterosIván Perdomo Ramírez
Jul 28, 2021·Current Problems in Cardiology·Ashot Avagimyan

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