Risk factor exposure among hepatitis C virus RNA positive Swedish blood donors--the role of parenteral and sexual transmission

Scandinavian Journal of Infectious Diseases
S ShevG Norkrans

Abstract

The potential modes of transmission for hepatitis C virus (HCV) infections were studied using a multivariate analysis of risk factor exposure among 51 2nd generation anti-HCV and HCV-RNA positive and matched anti-HCV negative blood donors. The following variables were found to be independently associated with anti-HCV and HCV-RNA positivity: intravenous drug use (IVDU) (p < 0.001), blood transfusion (p < 0.01), tattoos (p < 0.001), previous hospitalization (p < 0.05), history of sexually transmitted disease (STD) (p < 0.001) and lack of travels outside of Europe (p < 0.05). Among the 23 HCV-RNA positive donors without a history of IVDU or blood transfusion, an increased frequency of hospitalization (p = 0.017) and history of STD (p = 0.023) were found. Five of 22 sexual partners of the 51 index blood donors were HCV-RNA positive and in one of these couples sexual transmission was suspected. Anti-HCV and HCV-RNA positive donors were more often seropositive for herpes simplex virus type 2 (HSV-2) antibodies than were HCV-negative controls (p = 0.015). Sexual transmission of HCV may occur, but the possible role of HSV-2 requires further investigation.

References

Dec 1, 1992·Journal of Medical Virology·Y C KoP Y Chang
May 1, 1992·The Journal of General Virology·S W ChanP Simmonds
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·H NorrgrenE Nordenfelt
Dec 1, 1992·Annals of Internal Medicine·R WejstålG Norkrans
Nov 15, 1991·Annals of Internal Medicine·M E EysterJ J Goedert
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H H HsuH B Greenberg
Aug 17, 1991·Lancet·N Abildgaard, N A Peterslund
Apr 1, 1990·Annals of Internal Medicine·J E EverhartJ H Hoofnagle
Feb 1, 1991·Journal of Medical Virology·K KiyosawaH Suzuki
Nov 1, 1991·Infection·S Riestra MenéndezL Rodrigo Sáez
Jan 1, 1991·Scandinavian Journal of Infectious Diseases·A WidellE Nordenfelt
Sep 1, 1989·JAMA : the Journal of the American Medical Association·M J AlterH S Margolis
Feb 19, 1988·JAMA : the Journal of the American Medical Association·S D HolmbergA J Nahmias
Sep 9, 1988·JAMA : the Journal of the American Medical Association·W E StammL Corey
Nov 1, 1983·Journal of Clinical Microbiology·S JeanssonB Svennerholm
Jul 24, 1993·Lancet·D BrestersP N Lelie
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L ChemelloA Alberti
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L SerfatyR Poupon
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HondaS Murakami
Jan 20, 1993·JAMA : the Journal of the American Medical Association·D H OsmondA Reingold
Jan 20, 1993·JAMA : the Journal of the American Medical Association·H S WeinstockL B Polish
Jan 1, 1993·Journal of Hepatology·G J Kotwal

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Citations

Jan 6, 2000·Journal of Hepatology·R Wejstål
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L Rasmussen
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melissa A MarxDavid D Celentano
Mar 4, 2008·BMC Infectious Diseases·Charles E RamarokotoLeon P Rabarijaona
Feb 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rania A Tohme, Scott D Holmberg
Mar 8, 2012·The American Journal of the Medical Sciences·Mary Jane BurtonEdward W Hook
Nov 28, 2013·Infectious Disease Clinics of North America·Linda Gorgos
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ann-Sofi DubergKarl Ekdahl
Nov 15, 2011·European Journal of Internal Medicine·Homa RamezaniSeyed Moayed Alavian
Dec 18, 2014·Scandinavian Journal of Gastroenterology·Ann-Sofi DubergSoo Aleman
Nov 21, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Norma de Paula Cavalheiro
Mar 13, 1998·Journal of Medical Virology·S ShevA Widell
Apr 12, 2000·Journal of Viral Hepatitis·Z AckermanO Paltiel
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Seyed Moayed AlavianSadegh Masarrat
Jul 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·F M TenganA A Barone
Aug 10, 2002·BMC Gastroenterology·Ajacio B M Brandão, Sandra Costa Fuchs
Apr 14, 2010·Scandinavian Journal of Gastroenterology·Lóa DavídsdóttirRolf Hultcrantz
Jul 29, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Viktor DahlGustaf Edgren

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