Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias

World Journal of Urology
Kimihiko MoriyaNobuo Shinohara

Abstract

The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS. Among those with a history of HS surgery, patients in whom endocrinological evaluation regarding pituitary-gonadal axis was performed at 15 years of age or older between March 2004 and April 2018 were enrolled in the present study. High serum FSH was defined as greater than 10 mIU/ml. The severity of HS was divided into mild and severe. Factors affecting the post-pubertal high serum FSH were estimated. Seventy-nine patients were included in the present study. The severity of HS was mild in 35 and severe in 44. History of undescended testis (UDT) was confirmed in 12. High serum FSH was detected in nine. On logistic regression model analysis, a history of UDT was the only significant factor for high serum FSH. The incidence of high serum FSH in patients with UDT was significantly higher than that in those without UDT (58.3% vs 7.5%, p < 0.01). When stratified by severity of HS and the presence of UDT, high serum FSH was detected in 70% in patients with severe HS and UDT, whereas l...Continue Reading

References

Aug 1, 1990·The Journal of Urology·J P GearhartG D Berkovitz
Jan 1, 1988·Pediatric Annals·S B Levitt, E F Reda
Jul 13, 1999·Epidemiology·J B Klotz, L A Pyrch
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·A-M AnderssonN E Skakkebaek
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Rodolfo A ReyFernando G Cassorla
Sep 26, 2006·European Urology·Stephen J BromageStephen R Payne
Apr 25, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Teresa Sir-PetermannFernando Cassorla
Mar 14, 2009·International Journal of Andrology·C AsklundN Jørgensen
Feb 6, 2010·International Journal of Andrology·N JørgensenN E Skakkebaek
Aug 24, 2010·The Journal of Urology·Kimihiko MoriyaKatsuya Nonomura
Dec 18, 2012·Human Reproduction Update·N SermondadeS Czernichow
Jan 2, 2015·Fertility and Sterility·Céline FaureUNKNOWN ALIFERT Collaborative Group
Mar 3, 2015·Journal of Pediatric Urology·Giacinto MarroccoRoberto Piergentili
Sep 27, 2015·Human Reproduction·R J HartD J Handelsman
Jan 27, 2016·Journal of Pediatric Urology·A SpringerS Baumann
Sep 23, 2016·Journal of Clinical and Diagnostic Research : JCDR·Sanjay KumarNeeraj Agarwal
Jan 21, 2017·Human Reproduction·B W WhitcombG M Buck Louis

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Citations

Dec 3, 2020·International Journal of Impotence Research·Murat GulMesrur Selcuk Silay

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