PMID: 2504340Jul 8, 1989Paper

Risk factors and 25 year risk of coronary heart disease in a male population with a high incidence of the disease: the Finnish cohorts of the seven countries study

BMJ : British Medical Journal
J PekkanenM J Karvonen

Abstract

To assess the efficacy of high serum cholesterol concentration, raised blood pressure, and smoking as predictors of coronary heart disease. Prospective cohort study of middle aged men conducted over 25 years. Finish components of an ongoing international study (seven countries study). 1520 Men who at age 40-59 in 1959 were free of clinically evident heart disease. At each follow up visit a detailed medical examination including resting electrocardiography was performed, blood pressure and serum total cholesterol concentration were measured, and smoking was assessed. 825 Deaths (54% of participants) occurred during follow up, of which 335 were due to coronary heart disease. The hazard ratio for death from coronary heart disease with respect to risk factors at entry were: for serum cholesterol concentrations above 8.4 mmol/l v below 5.2 mmol/l, 2.68 (95% confidence interval 1.62 to 4.42); for systolic blood pressure in the highest quintile v that in the lowest quintile, 2.46 (1.72 to 3.50); and for smoking 10 or more cigarettes daily v never smoking, 1.95 (1.36 to 2.79). The hazard ratios with respect to cholesterol concentrations and blood pressure remained constant during follow up but the ratio with respect to smoking diminish...Continue Reading

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Citations

Jun 1, 1995·Journal of Community Health·M N NguyenL Delisle
Mar 1, 1990·Aging : Clinical and Experimental Research·U K LammiM Karvonen
Jan 31, 2013·Sleep & Breathing = Schlaf & Atmung·A Muraja-MurroJ Töyräs
Oct 18, 1990·The New England Journal of Medicine·J E RossouwB M Rifkind
Jul 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·R C PageR C Turner
Mar 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·M I McCarthyJ Tuomilehto
Jul 1, 1991·Journal of Clinical Pathology·F V Flynn
Apr 1, 1990·Postgraduate Medical Journal·L D Smith, D J Coltart
Jan 15, 2010·Annual Review of Public Health·Pekka Puska, Timo Ståhl
Jun 10, 2009·Circulation·Michael J PencinaRamachandran S Vasan
May 1, 1992·Public Health·J S Horner
Jul 9, 2010·Lancet·Jean Claude N MbanyaSostanie T Enoru
Oct 20, 2012·Revista Española De Cardiología·Irene R DéganoJaume Marrugat
Mar 31, 1998·Journal of Epidemiology and Community Health·J O HarlandK G Alberti
Feb 19, 1999·Journal of Epidemiology and Community Health·J WooE D Janus
Aug 18, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jani RankinenJussi Hernesniemi

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