Risk factors and antibiotic resistance of pneumonia caused by multidrug resistant Acinetobacter baumannii in pediatric intensive care unit

World Journal of Emergency Medicine
Xiao-Fang CaiWen-Bin Li

Abstract

With beta-lactam drugs and immunosuppressants widely used, the infection caused by Acinetobacter baumannii (Ab) has become more and more serious with multidrug resistant Acinetobacter baumannii (MDRAb) emerging and worsening rapidly. Compared with other patients, the incidence and multidrug resistance of MDRAb are higher in children in pediatric intensive care unit (PICU) because of immune deficiency, severe basic diseases, prolonged hospitalization and invasive operations. Hence it is significant to study the epidemiology and changes of antibacterial susceptibility in order to reduce the incidence of MDRAb in children. A total 115 patients with MDRAb pneumonia and 45 patients with negative MDRAb (NMDRAb) pneumonia who had been treated from January 2009 to August 2011 were studied retrospectively at the PICU of Wuhan Children's Hospital. Clinical data were analyzed with univariate and multivariate Logistic regression. In 176 clinical strains of Acinetobacter baumannii isolated, there were 128 strains of MDRAb, accounting for 72.73%. Drug susceptibility tests showed that the resistance rates of β-lactam antibiotics were more than 70% except for cefoperazone sulbactam. The rates to carbapenems were higher than 90%. They were sign...Continue Reading

References

Mar 21, 2008·The New England Journal of Medicine·L Silvia Munoz-Price, Robert A Weinstein
Nov 26, 2008·Antimicrobial Agents and Chemotherapy·Alejandro BeceiroUNKNOWN Spanish Group for Nosocomial Infection (GEIH)
Dec 19, 2008·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Cheng-Hong YangLi-Yeh Chuang
Mar 1, 2011·International Journal of Antimicrobial Agents·Hao-Yuan LeeCheng-Hsun Chiu

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Citations

Aug 1, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Theodoros KarampatakisEmmanuel Roilides
Jan 1, 2013·World Journal of Emergency Medicine·Hua-Zhong ZhangLi Qiao

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