Risk factors and antibiotic therapy in P. aeruginosa community-acquired pneumonia

Respirology : Official Journal of the Asian Pacific Society of Respirology
Oriol SibilaMarcos I Restrepo

Abstract

Current guidelines recommend empirical treatment against Pseudomonas aeruginosa in community-acquired pneumonia (CAP) patients with specific risk factors. However, evidence to support these recommendations is limited. We evaluate the risk factors and the impact of antimicrobial therapy in patients hospitalized with CAP due to P. aeruginosa. We performed a retrospective population-based study of >150 hospitals. Patients were included if they had a diagnosis of CAP and P. aeruginosa was identified as the causative pathogen. Univariate and multivariate analyses were performed using the presence of risk factors and 30-day mortality as the dependent measures. Seven hundred eighty-one patients with P. aeruginosa pneumonia were identified in a cohort of 62 689 patients with pneumonia (1.1%). Of these, 402 patients (0.6%) were included in the study and 379 (0.5%) were excluded due to health care-associated pneumonia or immunosuppression. In patients with CAP due to P. aeruginosa, 272 (67.8%) had no documented risk factors. These patients had higher rates of dementia and cerebrovascular disease. Empirical antibiotic therapy against P. aeruginosa within the first 48 h of presentation was independently associated with lower 30-day mortali...Continue Reading

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Citations

Mar 22, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pyng LeeJosé M Porcel
Mar 10, 2016·Current Opinion in Pulmonary Medicine·Oriol SibilaMarcos I Restrepo
Sep 2, 2016·Current Opinion in Critical Care·Charles Feldman, Ronald Anderson
Nov 12, 2015·Intensive Care Medicine·Cristina Vazquez Guillamet, Marin H Kollef
Jul 7, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ana Rodrigo-Troyano, Oriol Sibila
Aug 7, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·David VillafuerteUNKNOWN GLIMP Investigators
Mar 3, 2017·Current Infectious Disease Reports·Francisco Arancibia, Mauricio Ruiz
Sep 2, 2021·Annals of the American Thoracic Society·Antoni Torres, Michael S Niederman

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