Risk factors and clinical indicators for the development of biliary strictures post liver transplant: Significance of bilirubin

World Journal of Transplantation
Elizabeth Ann ForrestJonathan Fawcett

Abstract

To identify risk factors associated with the formation of biliary strictures post liver transplantation over a period of 10-year in Queensland. Data on liver donors and recipients in Queensland between 2005 and 2014 was obtained from an electronic patient data system. In addition, intra-operative and post-operative characteristics were collected and a logistical regression analysis was performed to evaluate their association with the development of biliary strictures. Of 296 liver transplants performed, 285 (96.3%) were from brain dead donors. Biliary strictures developed in 45 (15.2%) recipients. Anastomotic stricture formation (n = 25, 48.1%) was the commonest complication, with 14 (58.3%) of these occurred within 6-mo of transplant. A percutaneous approach or endoscopic retrograde cholangiography was used to treat 17 (37.8%) patients with biliary strictures. Biliary reconstruction was initially or ultimately required in 22 (48.9%) patients. In recipients developing biliary strictures, bilirubin was significantly increased within the first post-operative week (Day 7 total bilirubin 74 μmol/L vs 49 μmol/L, P = 0.012). In both univariate and multivariate regression analysis, Day 7 total bilirubin > 55 μmol/L was associated with...Continue Reading

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Citations

Jan 18, 2019·Biomédica : revista del Instituto Nacional de Salud·Nelson Jose Alvis-ZakzukFernando Pío De la Hoz
Jul 19, 2019·The American Journal of Gastroenterology·Nahum Méndez-SánchezMarco Arrese
Jan 12, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Cécile Jarlot-GasCharlotte Maulat

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