Risk factors and clinical outcomes of breakthrough yeast bloodstream infections in patients with hematological malignancies in the era of newer antifungal agents

Medical Mycology
Si-Hyun KimJong-Wook Lee

Abstract

Although yeast bloodstream infections (BSIs) are increasingly being reported in patients with hematological malignancies undergoing antifungal therapy, clinical information regarding breakthrough infections is scarce. The aim of this study was to determine the risk factors for and clinical outcomes of breakthrough yeast BSIs in patients with hematological malignancies in the era of newer antifungal agents. Between 2011 and 2014, all consecutive patients with hematological malignancies who developed yeast BSIs were included in a case-control study wherein breakthrough infections (cases) and de novo infections (controls) were compared. Of 49 patients with yeast BSIs, 21 (43%) met the criteria for breakthrough infections. The proportions of Candida krusei and Candida tropicalis in the cases and controls were significantly different (32% [7/22] vs. 3% [1/29], P = .015; 5% [1/22] vs. 38% [11/29], P = .007, respectively). Acute leukemia, presence of a central venous catheter and neutropenia in the 3 days prior to BSI were significant risk factors for breakthrough infections. Six-week mortality rates was 33% [7/21] in the cases and 43% [12/28] in the controls (P = .564). Refractory neutropenia and the Pitt bacteremia score were indepe...Continue Reading

References

Mar 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A Blumberg, A C Reboli
Mar 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H Rex
Feb 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M NucciW Pulcheri
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·O UzunJ H Rex
Nov 10, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Nucci, E Anaissie
Apr 17, 2002·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Nucci, A L Colombo
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vladimir C Krcmery, Robert Babela
Sep 25, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dimitrios P KontoyiannisIssam I Raad
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L PaganoF Aversa
Apr 24, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Richardson, C Lass-Flörl
Jul 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brahm H SegalBen E De Pauw
Jun 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard A MermelDavid K Warren
Jul 21, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S C A ChenUNKNOWN Australian Candidaemia Study
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
Oct 28, 2011·Expert Review of Anti-infective Therapy·Morena CairaLivio Pagano
Nov 22, 2011·The Journal of Infection·Maria N ChitasombatDimitrios P Kontoyiannis
Jun 2, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S-H KimJ W Sohn
Jul 31, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M N GamaletsouN V Sipsas
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN European Confederation of Medical Mycology
May 29, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I Oren, M Paul
Jun 26, 2014·Mycoses·Georg Maschmeyer, Thomas F Patterson
Feb 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Puig-AsensioUNKNOWN REIPI
Jan 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel

❮ Previous
Next ❯

Citations

Mar 15, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Xiao-Chen ChenDe-Pei Wu
Aug 4, 2020·Mycoses·Jeffrey D JenksMartin Hoenigl
Jan 16, 2020·Mycopathologia·Anastasia WasylyshynMarisa H Miceli
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Truc Thi Huong DinhPatcharee Ritprajak
Oct 26, 2021·Mycoses·Maria Ilaria Del PrincipeUNKNOWN Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.