Risk Factors and Comorbidities in Chronic Rhinosinusitis

Current Allergy and Asthma Reports
Derrick TintElina Toskala

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous disorder that creates a significant burden on the healthcare system. It is caused by a combination of inflammatory, environmental, and host factors; however, the precise mechanism of how each factor leads to CRS continues to be a source of debate. Previous data regarding this topic is often inconsistent or of lower quality. In this article, we review the recent literature on the risk factors and comorbidities in CRS. Large population-based studies have helped establish smoking as a significant risk factor for CRS. The focus has now shifted towards smoking and its effect on long-term outcomes after endoscopic sinus surgery (ESS). Ciliary dyskinesia, both primary and secondary, can affect both the sinonasal cavity and lower airways simultaneously by decreasing the beat frequency of cilia and inducing mucostasis. The effects of secondary dyskinesia may be reversible and there is some evidence to suggest the use of topical mucolytics in patients with CRS. Allergy and variants of sinonasal anatomy have been hypothesized to increase the risk of developing CRS by inducing chronic inflammation and obstructing the sinus ostia. Nevertheless, emerging data regarding these topics continue to ...Continue Reading

References

Jan 1, 1977·The Journal of Allergy and Clinical Immunology·G A Settipane, F H Chafee
Apr 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J L FergusonW J Martin
Sep 1, 1988·Journal of Computer Assisted Tomography·S J ZinreichA E Rosenbaum
Dec 1, 1987·Archives of Internal Medicine·H J SchwartzR J Ross
May 1, 1968·Annals of Internal Medicine·M Samter, R F Beers
Feb 2, 1994·JAMA : the Journal of the American Medical Association·L J NewmanC W Gross
Jun 1, 1993·Archives of Otolaryngology--head & Neck Surgery·J NuutinenS Joki
Oct 23, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D C Lanza, D W Kennedy
Jan 13, 1999·Clinical Otolaryngology and Allied Sciences·N S JonesA Davis
Feb 1, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Y T PangJ A Wilson
Aug 9, 2003·The Annals of Otology, Rhinology, and Laryngology·Leif JohanssonMats Bende
Jul 29, 2006·American Journal of Rhinology·Bei ChenNoam A Cohen
Oct 31, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Melanie M CollinsJanet A Wilson
Jun 27, 2007·The Journal of Laryngology and Otology·C M Philpott, D C McKiernan
Jul 12, 2007·American Journal of Rhinology·Bei ChenNoam A Cohen
Jul 24, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J Ulrich SommerBoris A Stuck
Nov 30, 2010·Respiratory Medicine·José Maria GuilemanyJoaquim Mullol
Jan 22, 2011·PloS One·Natalia Goldstein-DaruechNoam A Cohen
Jul 7, 2011·International Forum of Allergy & Rhinology·Bruce K TanRobert C Kern
Jul 7, 2011·International Forum of Allergy & Rhinology·Luke RudmikTimothy L Smith
Dec 22, 2011·American Journal of Rhinology & Allergy·Claudia LillDietmar Thurnher
Jan 31, 2012·International Forum of Allergy & Rhinology·Alexander G ChiuNoam A Cohen
Mar 2, 2012·Allergy, Asthma & Immunology Research·Sun-Hee ChoiYeong-Ho Rha
Mar 7, 2012·American Journal of Rhinology & Allergy·David GudisNoam A Cohen
Apr 24, 2012·The Laryngoscope·Nathan S AlexanderBradford A Woodworth
Jun 15, 2012·International Forum of Allergy & Rhinology·Douglas D RehTimothy L Smith
Sep 28, 2012·The Annals of Otology, Rhinology, and Laryngology·Orhan GörgülüYücel Akbaş
Oct 11, 2012·Seminars in Respiratory and Critical Care Medicine·Andrew A White, Donald D Stevenson
Jan 3, 2013·International Forum of Allergy & Rhinology·Hyun Sil Lee, Jean Kim
Jan 8, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ricardo Cassiano DemarcoWilma T Anselmo-Lima
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Bruce K TanBrian S Schwartz
Jul 3, 2013·International Forum of Allergy & Rhinology·Rishi VashishtaRodney J Schlosser
Jul 25, 2013·International Forum of Allergy & Rhinology·Vijay R RamakrishnanTodd T Kingdom
Oct 24, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jing ZhangHuabin Li
Nov 26, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Elisabetta PaceMark Gjomarkaj
Jan 17, 2014·International Forum of Allergy & Rhinology·Ilyes BeraniaMartin Desrosiers

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Citations

Feb 22, 2018·Journal of Occupational and Environmental Medicine·Ulrika K E ClarhedAnne Kristin Fell
Oct 20, 2018·Occupational and Environmental Medicine·Barbara PutmanMichael D Weiden
Jan 19, 2018·The Journal of Laryngology and Otology·G LeoG V Zuccotti
Aug 7, 2019·Asia Pacific Allergy·Sakinah MohamadNorasnieda Md Shukri
Mar 16, 2017·International Forum of Allergy & Rhinology·Andrey FilimonovJean Anderson Eloy
Nov 28, 2018·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Ahmed M YoussefMohamed Taha
Jul 27, 2018·Current Allergy and Asthma Reports·Wei-Jie GuanDe Yun Wang
Oct 29, 2020·The Annals of Otology, Rhinology, and Laryngology·Ramin ZojajiSoheil Shomeiri
Feb 5, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·W BehrR Birk
Oct 31, 2020·Nature Reviews. Disease Primers·Claus BachertWoo-Jung Song
Oct 27, 2020·International Archives of Otorhinolaryngology·Masa PetrovicNarine Vardanyan

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