Risk Factors and Main Indications for Palivizumab Prophylaxis in a Second Season Population: Results From the German Synagis Registry 2009-2016

The Pediatric Infectious Disease Journal
A SimonStefan Wagenpfeil

Abstract

After national recommendations, palivizumab is administered in Germany to high-risk infants to prevent hospitalizations related to respiratory syncytial virus (RSV) infection. Limited data are available to characterize those children who receive palivizumab in 2 consecutive RSV seasons. This was a comparative analysis of data from a postmarketing observational study (German SYNAGIS Registry, AbbVie Germany GmbH & Co.KG, Wiesbaden) detailing RSV-related risk factors and main indications for palivizumab in 920 children who received at ≥1 palivizumab injection in a second season between 2010 and 2016 [second season population (SSP)]. Median birth weight and gestational age at birth as well as the proportion of children with hemodynamically significant congenital heart disease, with any form of chronic lung disease of prematurity or with any form of neuromuscular impairment, were significantly higher in the SSP. Accordingly, hemodynamically significant congenital heart disease, chronic lung disease and other reasons (including neuromuscular impairment) and not prematurity were the main indications for palivizumab in the SSP. The RSV-related hospitalization rate confirmed by viral testing in the SSP (receiving palivizumab prophylaxi...Continue Reading

References

Nov 1, 1995·European Journal of Pediatrics·J Forster, R F Schumacher
Mar 1, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Thierry Lacaze-MasmonteilUNKNOWN Second Season Safety Study Group
May 15, 2003·Pediatric Pulmonology·Curt ParnesUNKNOWN Palivizumab Outcomes Registry Study Group
Nov 12, 2005·The Pediatric Infectious Disease Journal·Donald NullEdward Connor
May 10, 2013·The New England Journal of Medicine·Maarten O BlankenUNKNOWN Dutch RSV Neonatal Network
Jan 21, 2017·European Journal of Pediatrics·Daniel Y WangUNKNOWN CARESS Investigators

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Citations

Feb 12, 2019·Expert Review of Anti-infective Therapy·Bosco Paes, Xavier Carbonell-Estrany

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