PMID: 3770315Dec 1, 1986Paper

Risk factors and markers associated with proliferative retinopathy in patients with insulin-dependent diabetes

Diabetes
L C GroopE M Tolppanen

Abstract

To define risk factors and markers associated with proliferative retinopathy (PR), we compared 44 insulin-dependent diabetic patients with PR with 45 matched patients without advanced retinopathy (NR). Glycemic control assessed by HbA1 measurements from 5 yr preceding diagnosis of PR was significantly worse than in NR patients. The NR patients had more frequently been treated with multiple daily insulin injections than the PR patients. About half of the PR patients had Albustix-positive proteinuria, and these patients were further characterized by an abnormal lipid profile in plasma and increased frequency of cardiovascular disease. In contrast, PR patients without proteinuria did not differ from NR patients in these variables. Sensorimotor and autonomic neuropathy were twice as frequent in the PR than in the NR group. There was no correlation between anti-insulin antibody titer, immune complexes, and the presence of PR, but T-lymphocyte response to different stimuli was slightly reduced in the PR patients. The anti-insulin-antibody titer correlated with duration of diabetes in the NR but not the PR group. The frequency of HLA-DRw8 was slightly higher in the PR group than in the NR group (16 vs. 0%, NS), but we could not confir...Continue Reading

Citations

Jun 14, 2001·Journal of Advanced Nursing·J K LeksellK F Wikblad
Aug 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·J ErikssonL Groop
Feb 1, 1991·Postgraduate Medical Journal·G C MorrisM K Jones
Jun 15, 1988·American Journal of Ophthalmology·E F RosenlundK F Hanssen
Jan 1, 1990·Diabetes Research and Clinical Practice·A OhnedaM Sasaki
Jan 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·R W PeckJ R Hearnshaw
Nov 28, 1988·The American Journal of Medicine·M D Siperstein
Oct 1, 1990·Diabetes Research and Clinical Practice·K E Sussman
Nov 26, 1987·The New England Journal of Medicine·A S KrolewskiC R Kahn
Jun 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·T ScheininS Kontiainen

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