Risk factors and medico-economic effect of pancreatic fistula after pancreaticoduodenectomy

Gastroenterology Research and Practice
Renping HuangYinghui Guan

Abstract

The study aimed to uncover the risk factors for the new defined pancreatic fistula (PF) and clinical related PF (CR-PF) after pancreaticoduodenectomy (PD) surgery and to evaluate the medico-economic effect of patients. A total of 412 patients were classified into two groups according to different criteria, PF and NOPF according to PF occurrence: CR-PF (grades B and C) and NOCR-PF (grade A) based on PF severity. A total of 28 factors were evaluated by univariate and multivariate logistic regression test. Hospital charges and stays of these patients were assessed. The results showed that more hospital stages and charges are needed for patients in PF and CR-PF groups than in NOPF and NOCR-PF groups (P < 0.05). The excessive drinking, soft remnant pancreas, preoperative albumin, and intraoperative blood transfusion are risk factors affecting both PF and CR-PF incidence. More professional surgeons can effectively reduce the PF and CR-PF incidence. Patients with PF and CR-PF need more hospital costs and stages than that in NOPF and NOCR-PF groups. It is critical that surgeons know the risk factors related to PF and CR-PF so as to take corresponding therapeutic regimens for each patient.

References

Aug 1, 1977·The American Journal of Physiology·P D Navar, L G Navar
May 1, 1994·Surgical Endoscopy·M Gagner, A Pomp
Jan 7, 2004·Digestive Surgery·Claudio BassiPaolo Pederzoli
Jul 14, 2004·Archives of Surgery·C Max SchmidtJames A Madura
Nov 24, 2004·The American Journal of Gastroenterology·Tyler StevensGregory Zuccaro
Dec 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·John W LinKeith D Lillemoe
Jul 9, 2005·Surgery·Claudio BassiUNKNOWN International Study Group on Pancreatic Fistula Definition
Jun 24, 2006·Annals of Surgery·John L CameronKenneth A Belcher
Jan 26, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yasutoshi KimuraThomas R Gadacz
Oct 13, 2007·The British Journal of Surgery·G BalzanoV Di Carlo
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·S Y PengX J Cai
May 14, 2008·FEBS Letters·Marjolaine RocheEmmanuel Bourdon
May 23, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mark P CalleryCharles M Vollmer
Jun 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Giovanni ButturiniClaudio Bassi
Jun 13, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S MukherjeeA T Abraham
Oct 16, 2008·World Journal of Gastroenterology : WJG·Shailesh-V Shrikhande, Melroy-A D'Souza
Oct 30, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gregory A CotéUNKNOWN North American Pancreatitis Study Group
Nov 16, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicolò PecorelliMarco Braga
Nov 29, 2011·Asian Pacific Journal of Tropical Medicine·Dominic SophiaVelliyur Kanniapan Gopalakrishnan
Mar 7, 2012·The British Journal of Radiology·N FaccioliR Pozzi-Mucelli
May 23, 2012·International Journal of Surgical Oncology·Norman Oneil Machado
Aug 14, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jason W DenboStephen W Behrman
Nov 6, 2012·Journal of the American College of Surgeons·Mark P CalleryCharles M Vollmer
Feb 11, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Victor C NjokuKeith D Lillemoe

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Citations

May 25, 2016·Scandinavian Journal of Gastroenterology·Kjetil Søreide, Knut Jørgen Labori
Dec 2, 2017·ANZ Journal of Surgery·Mario GruppoRomeo Bardini

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pancreatectomy

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