Risk factors and mortality associated with multimorbidity in people with stroke or transient ischaemic attack: a study of 8,751 UK Biobank participants

Journal of Comorbidity
Katie I GallacherFrances S Mair

Abstract

Multimorbidity is common in stroke, but the risk factors and effects on mortality remain poorly understood. To examine multimorbidity and its associations with sociodemographic/lifestyle risk factors and all-cause mortality in UK Biobank participants with stroke or transient ischaemic attack (TIA). Data were obtained from an anonymized community cohort aged 40-72 years. Overall, 42 comorbidities were self-reported by those with stroke or TIA. Relative risk ratios demonstrated associations between participant characteristics and number of comorbidities. Hazard ratios demonstrated associations between the number and type of comorbidities and all-cause mortality. Results were adjusted for age, sex, socioeconomic status, smoking, and alcohol intake. Data were linked to national mortality data. Median follow-up was 7 years. Of 8,751 participants (mean age 60.9±6.7 years) with stroke or TIA, the all-cause mortality rate over 7 years was 8.4%. Over 85% reported ≥1 comorbidities. Age, socioeconomic deprivation, smoking and less frequent alcohol intake were associated with higher levels of multimorbidity. Increasing multimorbidity was associated with higher all-cause mortality. Mortality risk was double for those with ≥5 comorbidities c...Continue Reading

References

Jul 3, 2004·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinRonnie D Horner
Oct 22, 2008·Archives of Physical Medicine and Rehabilitation·Dan R BerlowitzW Bruce Vogel
Jun 17, 2010·Neuroepidemiology·Myles HortonRuth Ann Marrie
Jan 29, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Pedro Enrique Jiménez CaballeroIgnacio Casado Naranjo
Dec 24, 2013·Neurology·Morten SchmidtHenrik T Sørensen
Feb 4, 2014·European Journal of Clinical Pharmacology·R A PayneG A Abel
Jan 12, 2016·Disability and Rehabilitation·Valérie PoulinDeirdre R Dawson
Apr 16, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Debbie HebertRobert Teasell
May 12, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lorenzo FalsettiFrancesco Pellegrini
Aug 9, 2016·Archives of Gerontology and Geriatrics·Bruno Pereira NunesLuiz Augusto Facchini
Apr 5, 2017·Disability and Rehabilitation·Alan K H Tam, Mark T Bayley

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Citations

Aug 18, 2020·Primary Health Care Research & Development·Maria Raisa Jessica Ryc V AquinoJonathan Mant
Jun 25, 2019·Stroke; a Journal of Cerebral Circulation·Katie I GallacherFrances S Mair
Nov 12, 2020·The International Journal of Health Planning and Management·Chuang LiuYan Jiang
Nov 28, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Dearbhla M Kelly, Peter M Rothwell
Mar 18, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Gregory T RobbinsJeffrey C Schneider

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