Risk Factors and Outcome of C. difficile Infection after Hematopoietic Stem Cell Transplantation

Journal of Clinical Medicine
Chiara RosignoliFrancesca Patriarca

Abstract

Patients who undergo hematopoietic stem cell transplants (HSCT) are at major risk of C. difficile (CD) infection (CDI), the most common cause of nosocomial diarrhea. We conducted a retrospective study, which enrolled 481 patients who underwent autologous (220) or allogeneic HSCT (261) in a 5-year period, with the aim of identifying the incidence, risk factors and outcome of CDI between the start of conditioning and 100 days after HSCT. The overall cumulative incidence of CDI based upon clinical evidence was 5.4% (95% CI, 3.7% to 7.8%), without any significant difference between the two types of procedures. The median time between HSCT and CDI diagnosis was 12 days. Out of 26 patients, 19 (73%) with clinical and symptomatic evidence of CDI were positive also for enzymatic or molecular detection of toxigenic CD; in particular, in 5 out of 26 patients (19%) CD binary toxin was also detected. CDI diagnoses significantly increased in the period 2018-2019, since the introduction in the microbiology lab unit of the two-step diagnostic test based on GDH immunoenzymatic detection and toxin B/binary toxin/027 ribotype detection by real-time PCR. Via multivariate analysis, abdominal surgery within 10 years before HSCT (p = 0.002), antibio...Continue Reading

References

Jul 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Anand, A E Glatt
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Mar 6, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lise WillemsRégis Peffault de Latour
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolyn D AlonsoKieren A Marr
Dec 12, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Steven M TrifilioJayesh Mehta
Jun 29, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Seiji OhigashiHisashi Onodera
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B DebastUNKNOWN European Society of Clinical Microbiology and Infectious Diseases
Apr 10, 2014·International Journal of Hematology·Achuta Kumar GuddatiNanda Venu
May 6, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jackrapong BruminhentPhyllis Flomenberg
Jun 29, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mini KambojGenovefa Papanicolaou
Jul 28, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tania JainGeorge Alangaden
Nov 27, 2016·Applied Microbiology and Biotechnology·Christopher StaleyMichael J Sadowsky
Dec 13, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sol Del Mar AldreteRachel Friedman-Moraco
Jan 10, 2017·European Journal of Gastroenterology & Hepatology·Katarzyna RobakGrzegorz W Basak
May 26, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Carolyn D AlonsoCiarán P Kelly
Feb 11, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E R DubberkeT M Chiller
Mar 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L Clifford McDonaldMark H Wilcox
Jun 19, 2018·Journal of Clinical Gastroenterology·Gianenrico RizzattiAntonio Gasbarrini
Apr 5, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jacek CzepielGrażyna Biesiada
Nov 9, 2019·Applied Microbiology and Biotechnology·Chunlong Mu, Weiyun Zhu
Sep 29, 2020·Cancer Management and Research·Jinfei TongJianhua Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
hysterectomy

Software Mentioned

STATA16

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2021 Meta ULC. All rights reserved