Risk factors and outcome of patients with symptomatic intracranial stenosis presenting with lacunar stroke.

Stroke; a Journal of Cerebral Circulation
Amir KhanWarfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators

Abstract

We hypothesized that patients with intracranial stenosis with lacunar stroke presentations would face lower risks of recurrent stroke than those with index nonlacunar strokes, and that their recurrent strokes would predominantly be lacunar. We analyzed subjects enrolled with an index stroke into the Warfarin Aspirin Symptomatic Intracranial Disease (WASID) trial. The index stroke was classified as lacunar or nonlacunar. The primary end point was recurrent ischemic stroke. Cox proportional hazard models were generated with stratification for severity of stenosis. Three hundred forty-seven subjects were enrolled after an index stroke; 38 were lacunar and 309 were nonlacunar. Over a mean follow-up of 1.8 years, there was no significant difference in stroke recurrence between patients whose index stroke was lacunar (7 of 38 [18%]) versus nonlacunar (69 of 309 [22%]; hazard ratio, 0.79; 95% CI, 0.36-1.71). Furthermore, no significant differences were found when groups were stratified by 50% to 69% stenosis (hazard ratio, 0.50; 95% CI, 0.12-2.1) and ≥ 70% stenosis (hazard ratio, 0.87; 95% CI, 0.34-2.2). Of the 7 recurrent strokes in patients whose index stroke was lacunar, all 7 were nonlacunar and 3 were in the territory of the sten...Continue Reading

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Citations

Sep 7, 2013·Lancet·Adnan I Qureshi, Louis R Caplan
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Oct 19, 2013·Lancet Neurology·Christine A HolmstedtMarc I Chimowitz
Jul 6, 2014·Neurosurgery Clinics of North America·Mohamed S TelebOsama O Zaidat
Oct 10, 2013·Current Cardiology Reports·Tanya N TuranMarc I Chimowitz
Apr 10, 2020·Advances in Therapy·Marina Petrova KrastevaMirjam Rachel Heldner
Sep 30, 2017·Stroke and Vascular Neurology·Yulu Shi, Joanna M Wardlaw
Nov 27, 2019·Stroke; a Journal of Cerebral Circulation·Jose GutierrezMitchell S V Elkind
Oct 30, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mingyong Liu, Lichun Zhou
Aug 7, 2021·Journal of the American College of Cardiology·Jose GutierrezMitchell S V Elkind

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