Risk factors and outcomes of cytomegalovirus viremia in pediatric hematopoietic stem cell transplantation patients

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Jhong-Lin WuLi-Min Huang

Abstract

Cytomegalovirus (CMV) is a major pathogen causing significant mortality and morbidity in immunocompromised hosts. It is important to find risk factors associated with CMV viremia and its outcome. We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). Between August 2011 and March 2014, cases of pediatric HSCT patients at the National Taiwan University Children's Hospital were reviewed. Viremia was identified by plasma CMV real-time polymerase chain reaction (RT-PCR) assay. Eighteen (32%) of the 57 patients developed CMV viremia at a median of 23 days post-HSCT (range -3 to +721 days). Eighty-nine percent (16/18) of CMV viremia occurred within 100 days posttransplantation. Four patients finally had CMV diseases (1 with CMV colitis and 3 with CMV pneumonitis) and one patient died of CMV pneumonitis complicated with pulmonary hemorrhage and sepsis. Significant risk factors associated with CMV viremia via univariate analysis include older age (p = 0.03), leukemic patients [odds ratio (OR): 5.2, 95% confidence interval (CI): 1.52∼17.7, p = 0.008), allogeneic HSCT (OR: 14.57, 95% CI: 1.76∼120.5, ...Continue Reading

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Citations

Apr 18, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Konstantinos TsoumakasIoanna D Pavlopoulou
Apr 21, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cheng-Hsien LinChieh-Lin Jerry Teng
Feb 4, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Robyn SilcockJulia Clark

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