Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.

Journal of Burn Care & Research : Official Publication of the American Burn Association
Todd A WalrothRajiv Sood

Abstract

Methadone is an opioid commonly used for acute pain management in burn patients. One adverse effect of methadone is QTc interval prolongation, which may be associated with adverse cardiac outcomes. There is currently a paucity of data regarding risk of QTc prolongation in burn patients taking methadone and a lack of evidence-based recommendations for monitoring strategies in this population. The study objective was to determine the prevalence, risk factors, and cardiac outcomes related to methadone-associated QTc prolongation in adult burn patients. A total of 91 patients were included and were divided into groups according to maximum QTc. QTc prolongation was defined as greater than or equal to 470 ms (males) or 480 ms (females). There were no differences between groups regarding patient-specific risk factors, baseline QTc, or time to longest QTc. Patients in the prolonged QTc group had a higher rate of cardiac events (44% vs 9%; P < .001), higher median (IQR) change from baseline to longest QTc (61 ms [18,88] vs 23 ms [13,38]; P < .001), higher median (IQR) total daily dose of methadone (90 mg [53,98] vs 53 mg [30,75]; P = .004), and longer median (IQR) length of stay (53 [33,82] vs 35 [26,52] days; P = .008). QTc prolongatio...Continue Reading

References

Jan 1, 1990·Journal of Clinical Pharmacology·D D DensonP P Raj
Sep 17, 2002·Annals of Internal Medicine·Mori J KrantzPhilip S Mehler
Sep 26, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Lee Faucher, Kenneth Furukawa
Feb 10, 2010·Circulation·Barbara J DrewUNKNOWN American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular
May 29, 2010·Korean journal of anesthesiology·Billy Huh, Chan-Hong Park
Jul 22, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Vivek AgarwalPratik Pandharipande
Mar 17, 2012·Critical Care : the Official Journal of the Critical Care Forum·Raquel WanzuitaGlauco Adrieno Westphal
Jul 3, 2013·The American Journal of Drug and Alcohol Abuse·Ayman FareedKaren Drexler
Feb 1, 2014·Journal of Pain and Symptom Management·Lea C PriceRoberta Shanahan
Jun 12, 2016·Journal of Critical Care·Jessica L ElefritzMichael R Lyaker
Feb 12, 2017·Journal of Palliative Medicine·Katherine M JubaJack E Brown
Jul 19, 2018·Cardiovascular Toxicology·Mehdi SheibaniHossein Hassanian-Moghaddam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.