Risk factors and time to symptomatic presentation in leukaemia, lymphoma and myeloma

British Journal of Cancer
Debra A HowellL J L Forbes

Abstract

UK policy aims to improve cancer outcomes by promoting early diagnosis, which for many haematological malignancies is particularly challenging as the pathways leading to diagnosis can be difficult and prolonged. A survey about symptoms was sent to patients in England with acute leukaemia, chronic lymphocytic leukaemia (CLL), chronic myeloid leukaemia (CML), myeloma and non-Hodgkin lymphoma (NHL). Symptoms and barriers to first help seeking were examined for each subtype, along with the relative risk of waiting >3 months' time from symptom onset to first presentation to a doctor, controlling for age, sex and deprivation. Of the 785 respondents, 654 (83.3%) reported symptoms; most commonly for NHL (95%) and least commonly for CLL (67.9%). Some symptoms were frequent across diseases while others were more disease-specific. Overall, 16% of patients (n=114) waited >3 months before presentation; most often in CML (24%) and least in acute leukaemia (9%). Significant risk factors for >3 months to presentation were: night sweats (particularly CLL and NHL), thirst, abdominal pain/discomfort, looking pale (particularly acute leukaemias), and extreme fatigue/tiredness (particularly CML and NHL); and not realising symptom(s) were serious. T...Continue Reading

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Citations

Mar 11, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C LeoneA Truini
Jan 30, 2019·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Debra A HowellEve Roman
Mar 20, 2018·Journal of Medical Case Reports·Douglas A SalgueroWillaim Sierraalta
Oct 6, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Catherine AtkinElizabeth Sapey
Apr 25, 2019·Systematic Reviews·Catherine BellHelen McAneney
May 30, 2021·Chemico-biological Interactions·Elenilson F da SilvaSimone C B Gnoatto

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