Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients

AIDS
Timothy B DeppKristina Crothers

Abstract

To determine the association between HIV infection and other risk factors for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Longitudinal, national Veterans Aging Cohort Study including 43 618 HIV-infected and 86 492 uninfected veterans. AECOPD was defined as an inpatient or outpatient COPD ICD-9 diagnosis accompanied by steroid and/or antibiotic prescription within 5 days. We calculated incidence rate ratios (IRR) and 95% confidence intervals (CI) for first AECOPD over 2 years and used Poisson regression models to adjust for risk factors. Over 234 099 person-years of follow-up, 1428 HIV-infected and 2104 uninfected patients had at least one AECOPD. HIV-infected patients had an increased rate of AECOPD compared with uninfected (18.8 vs. 13.3 per 1000 person-years, P < 0.001). In adjusted models, AECOPD risk was greater in HIV-infected individuals overall (IRR 1.54; 95% CI 1.44-1.65), particularly in those with more severe immune suppression when stratified by CD4 cell count (cells/μl) compared with uninfected (HIV-infected CD4 < 200: IRR 2.30, 95% CI 2.10-2.53, HIV-infected CD4 ≥ 200-349: IRR 1.32, 95% CI 1.15-1.51, HIV-infected CD4 ≥ 350: IRR 0.99, 95% CI 0.88-1.10). HIV infection also modified the assoc...Continue Reading

References

Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M MossL A Brown
Feb 26, 2000·Annals of Internal Medicine·P T DiazT L Clanton
Sep 2, 2004·Respiratory Medicine·Jan B Oostenbrink, Maureen P M H Rutten-van Mölken
Feb 11, 2005·The New England Journal of Medicine·Richard Saitz
Nov 1, 2005·Alcohol·Joseph H SissonDavid M Mannino
Dec 3, 2005·Proceedings of the American Thoracic Society·Kyle I Happel, Steve Nelson
Jun 21, 2006·Annals of Internal Medicine·Peter K LindenauerEvan M Benjamin
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·Margaret K ElliottTodd A Wyatt
Nov 14, 2006·Chest·Kristina CrothersUNKNOWN Veterans Aging Cohort 5 Project Team
Jan 16, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pratibha C Joshi, David M Guidot
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Mary Y YehLou Ann S Brown
Sep 4, 2007·Alcohol·Joseph H Sisson
Sep 20, 2007·Proceedings of the American Thoracic Society·David M Mannino, Sidney Braman
Sep 20, 2007·Proceedings of the American Thoracic Society·Antonio AnzuetoFernando J Martinez
Jan 17, 2008·Chest·Karin H GroenewegenUNKNOWN COSMIC Study Group
Dec 5, 2008·Alcoholism, Clinical and Experimental Research·Gyongyi Szabo, Pranoti Mandrekar
Dec 9, 2008·Chest·Mark W HullJulio S G Montaner
Jan 1, 2008·Current Drug Abuse Reviews·Ping ZhangSteve Nelson
Sep 1, 2009·Lancet·Sundeep S Salvi, Peter J Barnes
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Matthew R GingoAlison Morris
Jul 10, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M Bradley DrummondChristian A Merlo
Aug 27, 2010·The Permanente Journal·Stanton T SiuArthur L Klatsky
Aug 31, 2010·PharmacoEconomics·Douglas W MapelJeno P Marton
Aug 31, 2010·American Journal of Respiratory and Critical Care Medicine·Mark D EisnerUNKNOWN Committee on Nonsmoking COPD, Environmental and Occupational Health Assembly
Sep 17, 2010·The New England Journal of Medicine·John R HurstUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Sep 21, 2010·American Journal of Respiratory and Critical Care Medicine·Kristina CrothersAmy C Justice
Mar 19, 2011·Annals of Epidemiology·H Nicole TranArthur L Klatsky
Jun 10, 2011·Proceedings of the American Thoracic Society·Kristina CrothersUNKNOWN Lung HIV Study
Jun 10, 2011·Proceedings of the American Thoracic Society·Alison MorrisUNKNOWN Lung HIV Study
Jul 9, 2011·The European Respiratory Journal·C R JenkinsP M A Calverley
Jul 30, 2011·Chest·Gavin C DonaldsonJadwiga A Wedzicha
Sep 14, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kathleen A McGinnisKristina Crothers
Nov 11, 2011·QJM : Monthly Journal of the Association of Physicians·B MesserS V Baudouin
Jan 17, 2012·American Journal of Respiratory and Critical Care Medicine·Catherine LaurinKim L Lavoie
Jan 31, 2012·Respiratory Medicine·Jessica A KynykJohn G Mastronarde
Feb 14, 2012·Respiration; International Review of Thoracic Diseases·Zinka MatkovicMarc Miravitlles
Mar 1, 2012·COPD·Carlos Martinez-RiveraJosep Morera

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