Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals.

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Yurdaguel ZopfHarald Dormann

Abstract

Since the 1970s, studies have examined potential risk factors associated with adverse drug reactions (ADRs) in a variety of settings. However, no pharmacoepidemiological study exists that incorporates clinical and laboratory parameters in a multiple regression model in order to consider predictors for ADRs. To characterize risk factors associated with ADRs in patients admitted to university hospital departments of internal medicine. Intensive pharmacovigilance was carried out in departments of internal medicine of two university hospitals. All admissions were followed prospectively for the occurrence of ADRs by members of a pharmacoepidemiological team consisting of physicians, pharmacologists and pharmacists. To identify patients at high risk for experiencing ADRs, patient histories and several clinical and laboratory data, determined at the time of admission, were taken into consideration. In addition to the drug prescribed, 40 parameters defined vital status at admission. These included temperature, heart rate, blood pressure (systolic-diastolic), body mass index, nicotine and alcohol use, and first laboratory test results after admission on nutrition status, inflammation, liver, kidney, pancreas or thyroid status, electroly...Continue Reading

References

Jan 1, 1979·The American Journal of the Medical Sciences·M LevyM Eliakim
May 1, 1975·Journal of Clinical Pharmacology·B J VakilV A Deshpande
Nov 1, 1991·Journal of the American Geriatrics Society·P CarboninA Sgadari
Oct 1, 1990·Journal of Internal Medicine·J HallasN Damsbo
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Jan 1, 1980·European Journal of Clinical Pharmacology·M LevyM Eliakim
Feb 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M CosentinoG Frigo
Feb 19, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S L GrayM Jalaluddin
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Nov 24, 1998·Journal of Clinical Pharmacology·C TranN H Shear
Feb 15, 2000·British Journal of Clinical Pharmacology·K FattingerP J Meier
Nov 10, 2000·Lancet·I R Edwards, J K Aronson
Jan 10, 2001·Alimentary Pharmacology & Therapeutics·H DormannH T Schneider
Apr 4, 2001·Alimentary Pharmacology & Therapeutics·P BlomqvistA Ekbom
Apr 25, 2001·European Journal of Clinical Pharmacology·R BordetJ Caron
Aug 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M D Drici, N Clément
Jan 5, 2002·American Journal of Clinical Dermatology·M Rademaker
Sep 26, 2002·Pharmacoepidemiology and Drug Safety·Graziano OnderUNKNOWN GIFA Study
Dec 11, 2002·Journal of the American Geriatrics Society·Graziano OnderGiovanni Gambassi
Dec 16, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Daniel W NebertElliot S Vesell
Feb 7, 2004·Pharmacoepidemiology and Drug Safety·M RameshG Parthasarathi
Jan 1, 1996·Pharmacoepidemiology and Drug Safety·L BowmanC D Black
May 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Nicole MittmannNeil H Shear
May 19, 2004·Journal of Internal Medicine·H DormannE G Hahn
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Oct 7, 2004·European Journal of Pharmacology·Daniel W Nebert, Elliot S Vesell
Nov 9, 2004·Archives of Gerontology and Geriatrics·Francisco CaamañoPierugo Carbonin
Feb 1, 2005·Pharmacoepidemiology and Drug Safety·Gianluca TrifiròAchille P Caputi
Mar 22, 2005·The Medical Journal of Australia·Christel L BurgessAnthony G Satti
Jan 6, 2006·European Journal of Clinical Pharmacology·Aline Lins CamargoIsabela Heineck
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Cornelis S van der HooftBruno H Ch Stricker
Apr 28, 2006·Pharmacotherapy·C A Bond, Cynthia L Raehl
May 25, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph T HanlonKenneth E Schmader
Sep 2, 2006·Pharmacoepidemiology and Drug Safety·Zoriah AzizNurul Suhaida Badarudin

❮ Previous
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Citations

Oct 3, 2009·European Journal of Clinical Pharmacology·Monica BergqvistEva Andersén Karlsson
Aug 7, 2010·European Journal of Clinical Pharmacology·Juan Francisco Sánchez Muñoz-TorreroAlicia Lorenzo Hernandez
Dec 15, 2011·European Journal of Clinical Pharmacology·Asia N RashedAntje Neubert
Sep 12, 2012·International Journal of Clinical Pharmacy·María Espinosa-BoschPaloma Villacorta-Linaza
Nov 20, 2012·Journal of Nutrition in Gerontology and Geriatrics·Roschelle Heuberger
May 31, 2012·Drugs & Aging·Antonio CherubiniFabrizia Lattanzio
Jul 11, 2012·Drugs & Aging·Balamurugan TangiisuranChakravarthi Rajkumar
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Offie P SoldinDonald R Mattison
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabrizia LattanzioAndrea Corsonello
Dec 23, 2015·Drugs -- Real World Outcomes·Abubakar Ibrahim JatauAb Fatah Ab Rahman
Mar 31, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacoline C BouvyMarc A Koopmanschap
Jul 28, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mulugeta Tarekegn AngamoLuke R E Bereznicki
Dec 5, 2013·Human & Experimental Toxicology·David E Amacher
Dec 10, 2017·European Journal of Clinical Pharmacology·Lina Zhou, Anamika Paul Rupa
Jul 3, 2013·Journal of Cutaneous Medicine and Surgery·Peter KoelblingerSteven R Feldman
Nov 15, 2018·Ciência & saúde coletiva·Kelly Lie NagaiNicolina Silvana Romano-Lieber
May 13, 2014·Pharmacoepidemiology and Drug Safety·Olatz UrbinaEsther Salas
Aug 6, 2019·Frontiers in Medicine·Carla TorreAna Paula Martins
Sep 16, 2014·Journal of Clinical Pharmacy and Therapeutics·A C M MartinsS Rozenfeld
Jun 12, 2019·European Journal of Clinical Pharmacology·Parvati B Patel, Tejas K Patel
Jul 5, 2012·Pharmacoepidemiology and Drug Safety·Ana MiguelAltamiro Costa Pereira
Sep 29, 2011·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Shih-Wei LaiDennis Paul Hsientang Hsieh
Jul 20, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Ursula KöberleKatrin Bräutigam
Jun 7, 2020·Biology of Sex Differences·Irving Zucker, Brian J Prendergast
Apr 22, 2011·Journal of Nursing Management·Ana Filipa MacedoFrancisco Batel Marques
Jun 25, 2020·MMW Fortschritte der Medizin·Sabine Gleich, Matthias Graw
Apr 5, 2018·International Journal of Clinical Pharmacy·Moza Al HailDerek Stewart
Jan 18, 2018·British Journal of Clinical Pharmacology·Nazanin FalconerNeil Cottrell
May 6, 2020·PloS One·Valdjane SaldanhaAntonio Gouveia Oliveira
Jul 13, 2019·Current Opinion in Pharmacology·Yasmin SchmidSimon M Mueller
May 8, 2018·Deutsches Ärzteblatt International·A Marlen SchurigJulia C Stingl
Apr 1, 2021·Computers, Informatics, Nursing : CIN·Thomas A BergTami Wyatt

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