Risk factors associated with adverse reactions to antituberculosis drugs

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Laíse Soares Oliveira Resende, Edson Theodoro Dos Santos-Neto

Abstract

This review sought to identify the available scientific evidence on risk factors associated with adverse reactions to antituberculosis drugs. We performed a systematic review of studies published in the 1965-2012 period and indexed in the MEDLINE and LILACS databases. A total of 1,389 articles were initially selected. After reading their abstracts, we selected 85 studies. Of those 85 studies, 16 were included in the review. Risk factors for adverse reactions to antituberculosis drugs included age > 60 years, treatment regimens, alcoholism, anemia, and HIV co-infection, as well as sodium, iron, and albumin deficiency. Protective factors against hepatic adverse effects of antituberculosis drugs included being male (combined OR = 0.38; 95% CI: 0.20-0.72) and showing a rapid/intermediate N-acetyltransferase 2 acetylator phenotype (combined OR = 0.41; 95% CI: 0.18-0.90). There is evidence to support the need for management of adverse reactions to antituberculosis drugs at public health care facilities.

References

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Citations

Jul 28, 2016·Human & Experimental Toxicology·E ElmorsyW G Carter
Dec 10, 2017·European Journal of Clinical Pharmacology·Lina Zhou, Anamika Paul Rupa
Aug 31, 2020·International Journal of Mycobacteriology·Madeeha LaghariZohra Bhatti
Nov 4, 2016·The American Journal of Case Reports·Martha Matos-TocascaBryan Valcarcel-Valdivia
Mar 12, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Carolina Miranda de Sousa LimaJocivânia Oliveira da Silva

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Methods Mentioned

BETA
acetylator

Software Mentioned

Office Excel
Epi Info

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