Risk factors associated with breast lymphedema

Annals of Surgical Oncology
Judy C BougheyAmy C Degnim

Abstract

The development of breast lymphedema (BLE) after breast/axillary surgery is poorly characterized. We prospectively evaluated clinical and surgical factors associated with development of BLE. Patients undergoing unilateral breast-conserving surgery were prospectively enrolled preoperatively and followed for development of BLE. To augment the number of patients with BLE for evaluation of risk factors, postoperative patients identified in the clinic with signs and symptoms of BLE were also enrolled. Logistic regression with Firth's penalized likelihood bias-reduction method was used for univariate and multivariate analysis. Of 144 women, 124 were enrolled preoperatively (38 of whom developed BLE), and 20 women with BLE were enrolled postoperatively. Any type of axillary surgery was the strongest factor associated with BLE (odds ratio, 134; 95 % confidence interval, 18 to >1,000). All 58 BLE events occurred in women with axillary surgery as compared with no events in the 46 patients without axillary surgery (p < 0.0001). Among 98 women who underwent axillary surgery, BLE did not occur more often after axillary lymph node dissection versus sentinel lymph node biopsy (p = 0.38) and was not associated with total number of nodes remove...Continue Reading

References

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Citations

Jul 5, 2016·The Breast Journal·Matthew E DoscherEvan S Garfein
Oct 18, 2016·American Journal of Surgery·Marten N BastaJohn P Fischer
Jul 12, 2018·Annals of Plastic Surgery·Benoit Ayestaray, Theodoros Chrelias
Nov 15, 2018·The New England Journal of Medicine·Stanley G Rockson
May 8, 2020·Breast Cancer Research and Treatment·Asha Heydon-WhiteKaren C Peebles
Feb 8, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Taynara Louisi PilgerFrancisco Jose Candido Dos Reis
Dec 29, 2020·Clinical Breast Cancer·Mohamed AbouelazayemSherif Monib
Aug 4, 2021·Journal of Plastic Surgery and Hand Surgery·Linda TallrothMagnus Becker
Sep 11, 2021·Annals of Surgical Oncology·Yara W KassamaniAlphonse G Taghian
Nov 19, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Colleen B KerriganMichelle M Sowden

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