Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
F López-MedranoSpanish Network for Research in Infectious Diseases (REIPI), the Group for the Study of Infection in Transplant Recipients (

Abstract

Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 kidney transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control recipients were matched (1:1 ratio) by center and date of transplantation. Overall mortality among cases was 60.8%, and 25.0% of living recipients experienced graft loss. Pretransplant diagnosis of chronic pulmonary obstructive disease (COPD; odds ratio [OR]: 9.96; 95% confidence interval [CI]: 1.09-90.58; p = 0.041) and delayed graft function (OR: 3.40; 95% CI: 1.08-10.73; p = 0.037) were identified as independent risk factors for IPA among those variables already available in the immediate peritransplant period. The development of bloodstream infection (OR: 18.76; 95% CI: 1.04-339.37; p = 0.047) and acute graft rejection (OR: 40.73, 95% CI: 3.63-456.98; p = 0.003) within the 3 mo prior to the diagnosis of IPA acted as risk factors during the subsequent period. In conclusion, pretransplant COPD, impaired graft function and the occurrence of serious posttransplant infections may be useful to identify KT recipients a...Continue Reading

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Citations

Oct 16, 2016·World Neurosurgery·Wonhyoung ParkDeok Hee Lee
Oct 10, 2018·Current Opinion in Infectious Diseases·Michelle K YongDimitrios P Kontoyiannis
Jan 26, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Seyed M Hosseini-MoghaddamJ Michael Paterson
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Nov 14, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Hernando TrujilloAmado Andrés

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