Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-1-infected offspring

Scientific Reports
Arthur M PaivaJorge Casseb

Abstract

HTLV-1 is transmitted primarily either through sexual intercourse or from mother to child. The mother/child pairs were classified as seroconcordant or serodiscordant. We analyzed mother to child transmission (MTCT) according to sociodemographic, clinical and epidemiological characteristics of the mother, child's gender and duration of breastfeeding. Between June 2006 and August 2016 we followed 192 mothers with HTLV-1 infection (mean age 41 years old), resulting in 499 exposed offspring, 288 (57.7%) of whom were tested for HTLV-1, making up the final sample for the study, along with their 134 respective mothers. Among the tested mother/child pairs, 41 (14.2%) were HTLV-1 positive, highlighted that seven of 134 family clusters concentrated 48.8% of positive cases. Variables associated with a positive child: breastfeeding duration ≥12 months, maternal PVL ≥100 copies/104 PBMC, mother's age at delivery >26 years old, and HTLV-1 in more than one child of the same mother. In a multiple logistic regression, breastfeeding ≥12 months, higher maternal PVL and ≥2 previous HTLV-1-infected children remained independently associated with the outcome. Thus, high maternal PVL and breastfeeding beyond 12 months were independently associated wi...Continue Reading

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Citations

Nov 13, 2018·PLoS Neglected Tropical Diseases·Carolina RosadasMarzia Puccioni-Sohler
Jun 17, 2020·Public Health Nutrition·Katherine BlackshawRichard B Banati
Jan 30, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Maria de Fátima Castro MendesMaria Rosa Quaresma Bomfim
May 14, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Rafael Xavier da SilvaAdele Caterino-de-Araujo
Feb 13, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Adele Caterino-de-AraujoRegina Célia Moreira
Feb 16, 2020·Retrovirology·Ricardo IshakAntonio Carlos R Vallinoto
Jan 1, 2020·Pathogens·Rosa Maria N MarcussoAugusto César Penalva de Oliveira
Apr 25, 2020·Frontiers in Microbiology·Kazuo ItabashiToshiki Watanabe
May 28, 2019·Frontiers in Microbiology·Carolina Rosadas, Graham P Taylor
Oct 20, 2020·The Journal of Clinical Investigation·Kenta TezukaIsao Hamaguchi
Dec 29, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Susanna GiachéLorenzo Zammarchi
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Carolina RosadasRicardo Ishak
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Carolina RosadasRicardo Ishak

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

Primer Express
IC
Stata

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