Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014

Virus Research
Ayumu OhnoYoko Aida

Abstract

Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, a malignant B cell lymphoma. BLV has spread worldwide and causes serious problems. After infection, the BLV genome is integrated into the host DNA and can be amplified during periods of latency. We previously designed degenerate primers using the Coordination of Common Motifs (CoCoMo) algorithm to establish a new quantitative real-time PCR method (BLV-CoCoMo-qPCR-2) of measuring the proviral load of both known and novel BLV variants. Here, we aimed to examine the correlation between proviral load and risk factors for BLV infection, such as breeding systems, parousity, and colostrum feeding. Blood and serum samples were collected from 83 BLV-positive farms in 22 prefectures of Japan, and the BLV proviral load and anti-BLV antibody levels were measured. BLV was detected in 73.3% (1039/1,417) of cattle by BLV-CoCoMo-qPCR-2 and the provirus was detected in 93 of 1039 antibody-negative samples. The results showed that the proviral load increased with progression of lymphocytosis. Next, the risk factors associated with increasing BLV infection rate were examined along with any association with proviral load. The proviral load was higher in cattle with lym...Continue Reading

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Citations

Mar 22, 2016·Archives of Virology·Shin-Nosuke TakeshimaYoko Aida
Apr 20, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·EunJung LeeYeun-Kyung Shin
Jan 17, 2019·Physiological Reviews·Arianna CalcinottoAndrea Alimonti
Jun 2, 2020·The Journal of Veterinary Medical Science·Dung Thi LETakeshi Haga
Oct 12, 2016·The Journal of Veterinary Medical Science·Yuka OkuwaYasuo Inoshima
Nov 4, 2017·Virology Journal·Meripet PolatYoko Aida
Dec 24, 2019·Frontiers in Veterinary Science·Jui-Chun HsiehShih-Te Chuang
Oct 23, 2020·The Journal of Veterinary Medical Science·Samy MetwallyYoko Aida
Nov 3, 2020·Frontiers in Veterinary Science·Rania HamadaYoko Aida
Jan 31, 2021·Animals : an Open Access Journal From MDPI·Abdelfattah SelimMohamed S Alyousif
Mar 21, 2021·Journal of Dairy Science·Alessa KuczewskiFrank van der Meer
Jun 28, 2020·Preventive Veterinary Medicine·Oscar J BenitezDaniel L Grooms
Aug 11, 2020·Virology·Hironobu MurakamiKenji Tsukamoto
Jul 10, 2021·Virology·Hironobu MurakamiKenji Tsukamoto

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