Risk factors associated with intrathyroid extension of thyroid microcarcinomas

Langenbeck's Archives of Surgery
Nikola SlijepcevicIvan Paunovic

Abstract

The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it. A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period. These patients had a PTMC incidentally discovered on definite histopathological findings following total or near-total thyroidectomy. Since distinguishing between intrathyroid extension of PTMC as the result of intrathyroid dissemination or as the result of multicentricity is challenging, we observed them together as multifocality. In statistical analysis, we used standard descriptive statistics and univariate and multivariate logistic regression analysis to determine independent risk factors associated with multifocality. In our study, there were 85.4% females and 14.6% males with a median age of 54 years. A multinodular goitre (32.5%) was the most common indication for an operation. Most patients (68.4%) had a PTMC that...Continue Reading

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Citations

Apr 3, 2020·Annals of the Royal College of Surgeons of England·M ShawkyT Abdel-Aziz
Nov 21, 2018·Reviews in Endocrine & Metabolic Disorders·Roberto VitaSalvatore Benvenga

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