Risk factors associated with portomesenteric venous thrombosis in patients undergoing restorative proctocolectomy for medically refractory ulcerative colitis

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Jinyu GuFeza H Remzi

Abstract

Data on risk factors for portomesenteric venous thrombosis (PMVT) following abdominal surgery for ulcerative colitis (UC) are limited. The aim of this study was to investigate factors associated with PMVT after surgical treatment for UC. Patients who underwent restorative proctocolectomy (RPC) and ileal pouch-anal anastomosis (IPAA) including diverting ileostomy closure for medically refractory UC were identified from a prospectively maintained database. Patient-related, disease-related and treatment-related variables were collected. Univariable and multivariable analyses were performed to assess factors associated with PMVT. Of the 521 patients completing surgical treatment for UC between 2006 and 2012, symptomatic PMVT occurred in 36 (7%), which resulted in a significantly increased hospital stay (P < 0.001). Patients developing PMVT were younger (P = 0.014), had a lower preoperative albumin level (P = 0.037) and were more likely to have been taking steroids within 1 month before surgery (P = 0.006). The combined incidence of PMVT was comparable between patients having a three-stage and two-stage management (6% vs. 8%, P = 0.43), but the relative incidence of PMVT after RPC + IPAA was 8%, significantly higher than the 4% afte...Continue Reading

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Citations

Jan 24, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Myung Jo KimSung-Bum Kang
Aug 26, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicholas P McKennaAmy L Lightner
Nov 5, 2019·The Surgical Clinics of North America·Lea Lowenfeld, Kyle G Cologne
May 5, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Amy L LightnerPhillip R Fleshner
Oct 13, 2021·Diseases of the Colon and Rectum·Maitri Patel, Traci Hedrick

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