Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.

BMC Pulmonary Medicine
Ivette Buendia-RoldanMoises Selman

Abstract

Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory asymptomatic individuals enrolled in our Lung Aging Program. From a cohort of 687 subjects, we found by high-resolution computed tomography (HRCT) 29 individuals (4%) with emphysematous changes that were compared with 87 controls (3:1) randomly selected from the same cohort. This was a transversal, observational, case-control study where we examined demographics and functional characteristics, as well as telomere length and serum Klotho concentration, two conditions that have been associated with aging and some aging-associated diseases including emphysema. Individuals with subclinical pulmonary emphysema were older (72 ± 9 versus 67 ± 6 years), and primarily smoker males with low body mass index. Despite that they were asymptomatic, two of them exhibited a decrease of forced expiratory volume in 1 s (FEV1), with a lower FEV1/FVC suggesting airway obstruction. Cigarette smoking (OR = 5.43, CI95% 1.8-16.7), family history of lung disease (OR = 4.32, CI95% 1.0-19.0) and lower body mass index (OR 7.22, CI95% 1.2-3.5) were risk ...Continue Reading

References

Nov 1, 1994·AJR. American Journal of Roentgenology·W M Thurlbeck, N L Müller
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Nov 26, 2009·Proceedings of the American Thoracic Society·Yoshinosuke Fukuchi
Feb 12, 2011·Chest·Craig P HershUNKNOWN COPDGene Investigators
Sep 20, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jodie BirchJoão F Passos
Dec 23, 2016·Annals of the American Thoracic Society·Susan E StanleyMary Armanios
Sep 21, 2017·Mutation Research. Reviews in Mutation Research·Younis Mohammad HazariKhalid Majid Fazili
Jun 26, 2018·Current Opinion in Pulmonary Medicine·Mario SilvaNicola Sverzellati
Jul 13, 2018·Orphanet Journal of Rare Diseases·María Torres-DuránFrancisco Dasí
Sep 14, 2018·American Journal of Respiratory and Critical Care Medicine·Moisés SelmanAnnie Pardo

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

PLATINO
GraphPad Prism
GraphPad
Stata

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