Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES

Pediatric Diabetes
Nan-Kai WangChang Gung Juvenile Diabetes Eye Study Group

Abstract

The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan. This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self-reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball. There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional-hazards analysis showed that older-onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration. Development of retinopathy 10 yr after diagnosis in people with juvenile-onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.

References

Oct 1, 1990·Diabetes Care·B E KleinR Klein
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 10, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·T DanneB Weber
Nov 5, 1999·Retina·L PierroG Calori
Apr 25, 2003·The Journal of Pediatrics·Rae-Ellen W KaveyUNKNOWN American Heart Association
Jul 2, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Timothy J LyonsRichard L Klein
Dec 24, 2004·Diabetes Care·Janet SilversteinUNKNOWN American Diabetes Association
Mar 1, 2007·Diabetes Care·Kendra VehikDana Dabelea
Sep 27, 2007·Ophthalmic Epidemiology·Barbara Eden Kobrin Klein
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Dec 25, 2009·Ophthalmology·Laurence Shen LimTien Yin Wong
Jan 11, 2011·Diabetes/metabolism Research and Reviews·Kendra Vehik, Dana Dabelea
Jun 4, 2011·Diabetologia·H P HammesUNKNOWN DPV-Wiss Study Group
Jan 14, 2012·The British Journal of Ophthalmology·Marla B SultanKui Huang
Jan 25, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·E J Mayer-DavisUNKNOWN SEARCH for Diabetes in Youth Study Group
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
May 26, 2012·Ophthalmology·Ryan Eyn Kidd ManEcosse L Lamoureux
Dec 12, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Der JiangLee-Ming Chuang

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Citations

Aug 17, 2018·Scientific Reports·Eugene Yu-Chuan KangUNKNOWN Chang Gung Juvenile Diabetes Eye Study Group
Nov 13, 2020·BMJ Open Diabetes Research & Care·Pablo Alvarez-RamosManuel Aguilar-Diosdado
Dec 5, 2020·Journal of Diabetes Research·Wenjun ShaLigang Zhou
Mar 25, 2019·Diabetes Research and Clinical Practice·Ferdinando Carlo SassoUNKNOWN NO BLIND Study Group

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