Risk Factors, Clinical Presentation, and Outcome of Acinetobacter baumannii Bacteremia

Frontiers in Cellular and Infection Microbiology
Tala BallouzEid Azar

Abstract

Infections caused by Acinetobacter baumannii (AB), an increasingly prevalent nosocomial pathogen, have been associated with high morbidity and mortality. We conducted this study to analyze the clinical features, outcomes, and factors influencing the survival of patients with AB bacteremia. We retrospectively examined the medical records of all patients developing AB bacteremia during their hospital stay at a tertiary care hospital in Beirut between 2010 and 2015. Ninety episodes of AB bacteremia were documented in eighty-five patients. Univariate analysis showed that prior exposure to high dose steroids, diabetes mellitus, mechanical ventilation, prior use of colistin and tigecycline, presence of septic shock, and critical care unit stay were associated with a poor outcome. High dose steroids and presence of septic shock were significant on multivariate analysis. Crude mortality rate was 63.5%. 70.3% of the deaths were attributed to the bacteremia. On acquisition, 39 patients had septicemia. Despite high index of suspicion and initiation of colistin and/or tigecycline in 18/39 patients, a grim outcome could not be averted and 37 patients died within 2.16 days. Seven patients had transient benign bacteremia; three of which were ...Continue Reading

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Citations

Jul 6, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Shuangshuang YangLiping Zhang
Dec 11, 2020·Virulence·Gema Labrador-HerreraMaría Eugenia Pachón-Ibáñez
Aug 11, 2019·American Journal of Infection Control·Iara RossiRosineide Marques Ribas
Jan 18, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Gizem Guner OzenenFerda Ozkinay
Dec 21, 2020·Journal of Infection and Public Health·Moustafa MoussallyZeina A Kanafan
Jul 15, 2021·The Pediatric Infectious Disease Journal·Anucha ThatrimontrichaiManapat Phatigomet

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