Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Margaret RosenfeldEPIC Study Group

Abstract

Risk factors for initial Pseudomonas aeruginosa (Pa) acquisition, particularly environmental exposures, are poorly understood. We aimed to identify such risk factors in order to inform prevention strategies and identify high-risk populations. The study cohort included all participants in the U.S. EPIC Observational Study who had no prior Pa-positive respiratory cultures (N=889). Cox proportional hazard models were used to test the effects of factors on age at first Pa-positive respiratory culture. Cystic fibrosis (CF) genotype functional class had an important effect on age at initial Pa acquisition (hazard ratio (HR) comparing minimal to residual CFTR function 2.87 (95% CI 1.88, 4.39)). None of the modifiable risk factors evaluated, including cigarette smoke, hot tub use, breastfeeding, or daycare, was associated with age at Pa acquisition. Similarly, newborn screening was not associated with age at Pa acquisition (HR 0.85, 95% CI 0.66, 1.09). Key associations were validated in a CF Foundation National Patient Registry replication cohort. Given the ubiquitous presence of Pa in the environment, it may be that many imposed lifestyle changes will have less impact on age at initial Pa acquisition than genetic determinants.

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References

Jul 1, 1990·The Pediatric Infectious Disease Journal·E KeremH Levison
Aug 26, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M De BraekeleerF Simard
Dec 6, 2000·The European Respiratory Journal·G DöringD J Touw
Jun 7, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lisa SaimanUNKNOWN Cystic Fibrosis Foundation
Aug 28, 2003·Annals of Human Genetics·Rebecca K Rowntree, Ann Harris
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gerd DöringUNKNOWN Consensus Study Group
Feb 3, 2005·JAMA : the Journal of the American Medical Association·Zhanhai LiMark L Splaingard
Feb 15, 2005·American Journal of Respiratory and Critical Care Medicine·Amanda L GriffithsDavid S Armstrong
Jul 19, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·N HøibyT Pressler
Oct 6, 2005·The Journal of Pediatrics·Erika J SimsUNKNOWN Steering Committee of the UK Cystic Fibrosis Database
Jan 18, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Tacjana PresslerNiels Høiby
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hirotoshi MatsuiRichard C Boucher
Jul 24, 2007·The Journal of Pediatrics·Michael W KonstanUNKNOWN Scientific Advisory Group and the Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
Jan 31, 2008·JAMA : the Journal of the American Medical Association·J Michael CollacoGarry R Cutting
Jul 22, 2008·The Journal of Pediatrics·Philip M FarrellUNKNOWN Cystic Fibrosis Foundation
Apr 24, 2009·American Journal of Physiology. Cell Physiology·Milan BajmocziDavid E Golan
Feb 6, 2010·The Journal of Pediatrics·UNKNOWN Cystic Fibrosis FoundationFrank J Accurso
Dec 8, 2009·Chest·Justin R OrtizChristopher H Goss
Apr 30, 2010·Science Translational Medicine·David A StoltzMichael J Welsh
Jul 3, 2010·Pediatric Pulmonology·Margaret RosenfeldUNKNOWN EPIC Study Group Participating Clinical Sites
Mar 15, 2011·Thorax·Sarath C RanganathanUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis

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Citations

Apr 2, 2014·American Journal of Respiratory and Critical Care Medicine·Edith T Zemanick, Frank J Accurso
May 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerie Waters
Jul 17, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Cori DainesUNKNOWN EPIC Investigators
Mar 20, 2014·Pediatric Pulmonology·Edith T ZemanickUNKNOWN EPIC Study Group
May 6, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Pieter C GoeminneLieven J Dupont
Oct 5, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sanja StanojevicFelix Ratjen
Jul 16, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lisa SaimanDavid J Weber
Jul 26, 2015·The Lancet. Respiratory Medicine·David C Taylor-RobinsonCraig Winstanley
Jan 17, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·J Stuart ElbornPatrick A Flume
Mar 8, 2016·Expert Review of Respiratory Medicine·K A RamsayT J Kidd
Jun 17, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·R Rivas Caldas, S Boisramé
Jan 17, 2015·Annals of the American Thoracic Society·Kevin J PsoterMargaret Rosenfeld
Jun 26, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K J PsoterM Rosenfeld
Jun 18, 2016·Journal of Clinical Pharmacy and Therapeutics·N EmiraliogluN Kiper
Jun 2, 2016·PloS One·Frederick R Adler, Theodore G Liou
Jan 18, 2017·Molecular and Cellular Pediatrics·Sébastien Boutin, Alexander H Dalpke
Jun 8, 2018·Journal of Clinical Microbiology·Peter H GilliganJohn E Moore
Sep 28, 2018·Pediatric Pulmonology·Heather HochScott D Sagel
Mar 21, 2019·Expert Review of Respiratory Medicine·Nicola J RowbothamAlan R Smyth
Sep 21, 2013·Current Opinion in Pulmonary Medicine·Kieran McIntyre
Oct 19, 2016·International Journal of Environmental Research and Public Health·Benjamin T KoppJudith A Groner
Jun 17, 2019·Thorax·Sabariah Noor HarunUNKNOWN Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) study group
Dec 9, 2016·BMC Pulmonary Medicine·Mathew R CrullChristopher H Goss
Sep 15, 2017·Pediatric Pulmonology·Aliza K FinkWayne J Morgan
Oct 20, 2020·International Journal of Neonatal Screening·Virginie ScotetPhilip M Farrell
Oct 20, 2020·International Journal of Neonatal Screening·Victoria ShermanSergey Kutsev
Nov 12, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lindsay Jackson, Valerie Waters
Feb 10, 2021·International Journal of Neonatal Screening·Virginie ScotetPhilip M Farrell
Nov 10, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Meghan E McGarryNgoc P Ly
May 11, 2021·FEMS Microbiology Reviews·Andreu Coello PelegrinAlex van Belkum
Aug 31, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marianne S MuhlebachLisa Saiman

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