Risk factors for anastomotic leak and postoperative morbidity and mortality after elective right colectomy for cancer: results from a prospective, multicentric study of 1102 patients

International Journal of Colorectal Disease
Matteo FrassonANACO Study Group

Abstract

Studies focused on postoperative outcome after oncologic right colectomy are lacking. The main objective was to determine pre-/intraoperative risk factors for anastomotic leak after elective right colon resection for cancer. Secondary objectives were to determine risk factors for postoperative morbidity and mortality. Fifty-two hospitals participated in this prospective, observational study (September 2011-September 2012), including 1102 patients that underwent elective right colectomy. Forty-two pre-/intraoperative variables, related to patient, tumor, surgical procedure, and hospital, were analyzed as potential independent risk factors for anastomotic leak and postoperative morbidity and mortality. Anastomotic leak was diagnosed in 93 patients (8.4 %), and 72 (6.5 %) of them needed radiological or surgical intervention. Morbidity, mortality, and wound infection rates were 29.0, 2.6, and 13.4 %, respectively. Preoperative serum protein concentration was the only independent risk factor for anastomotic leak (p < 0.0001, OR 0.6 per g/dL). When considering only clinically relevant anastomotic leaks, stapled technique (p = 0.03, OR 2.1) and preoperative serum protein concentration (p = 0.004, OR 0.6 g/dL) were identified as the on...Continue Reading

References

May 1, 1973·Annals of Surgery·T R SchrockJ E Dunphy
Apr 29, 1998·Diseases of the Colon and Rectum·H M MacRae, R S McLeod
Jul 27, 1999·The British Journal of Surgery·L T SørensenP Wille-Jørgensen
Feb 21, 2003·The British Journal of Surgery·P P TekkisA C J Windsor
Jun 7, 2003·Diseases of the Colon and Rectum·Jyrki T MäkeläSeppo Laitinen
May 14, 2004·The New England Journal of Medicine·UNKNOWN Clinical Outcomes of Surgical Therapy Study GroupDavid Ota
Nov 13, 2004·Diseases of the Colon and Rectum·Richard P BakerJohn R T Monson
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·S AnwarN A Scott
Mar 23, 2005·Archives of Surgery·Arnaud AlvesUNKNOWN Association Française de Chirurgie
Jul 5, 2005·The Lancet Oncology·Ruben VeldkampUNKNOWN COlon cancer Laparoscopic or Open Resection Study Group (COLOR)
Oct 20, 2006·Diseases of the Colon and Rectum·Hok-Kwok ChoiJudy W C Ho
Jan 25, 2007·Annals of Surgery·Neil HymanPeter A Cataldo
Nov 24, 2007·Journal of the American College of Surgeons·Nicolas VeyrieUNKNOWN French Associations for Surgical Research
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Apr 21, 2010·Archives of Surgery·Dana A TelemCelia M Divino
Nov 10, 2010·International Journal of Surgery·Edmund LeungLing S Wong
Aug 17, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hossein MasoomiMichael J Stamos
Jan 21, 2014·Cirugía española·Elias Rodriguez-CuellarPedro Ruiz Lopez
Oct 7, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C KontovounisiosP Tekkis
Nov 13, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F G MarinelloE García-Granero

❮ Previous
Next ❯

Citations

Mar 10, 2016·International Journal of Colorectal Disease·Ali Kagan Coskun, Ali Harlak
Jan 11, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·I S BakkerT Wiggers
Jul 10, 2016·International Journal of Colorectal Disease·Mikkel JessenPeter-Martin Krarup
Oct 26, 2016·Surgical Endoscopy·Alastair FungMarylise Boutros
Dec 9, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Urszula Zielińska-BorkowskaTomasz Skirecki
Sep 28, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·Z HircheS Willis
May 20, 2017·Polski przeglad chirurgiczny·Zbigniew BanaszkiewiczArkadiusz Jawień
Jun 20, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G PellinoUNKNOWN ANACO Study Group
Jun 20, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·UNKNOWN 2015 European Society of Coloproctology Collaborating Group
Nov 16, 2019·International Journal of Colorectal Disease·Leonardo SolainiGiorgio Ercolani
Oct 29, 2019·Cancer Biomarkers : Section a of Disease Markers·Yongming YuYisheng Cao
Sep 16, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Han Deok KwakJin Kim
Nov 2, 2019·Annals of the Royal College of Surgeons of England·L Sánchez-GuillénE García-Granero
Jun 12, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Adam LamJohn Alverdy
Aug 30, 2020·International Journal of Colorectal Disease·Chu Woon NgJoseph Cherng Huei Kong
Apr 25, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C ShwaartzC M Divino
Apr 30, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E EspinS Biondo
Jul 24, 2020·World Journal of Gastrointestinal Oncology·Jia-Nan ChenQian Liu
Jun 5, 2018·Annals of Gastroenterological Surgery·Motonari RiYasuyuki Seto
Jan 1, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·Stanislaus ArgenyStefan Riss
Aug 5, 2020·International Journal of Colorectal Disease·Zhaohui XuXin Chen
Mar 7, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·UNKNOWN 2015 European Society of Coloproctology collaborating group
Nov 21, 2018·Techniques in Coloproctology·T PoskusM Kryzauskas
Sep 20, 2019·International Journal of Molecular Sciences·Romain VillégerMathilde Bonnet
Apr 26, 2017·Antimicrobial Resistance and Infection Control·Aina GomilaUNKNOWN VINCat colon surgery group
Oct 30, 2020·Expert Review of Anticancer Therapy·Ingrid GarajováGodefridus J Peters
Jan 28, 2021·Surgical Endoscopy·Richard T SpenceSami A Chadi
Feb 8, 2020·Diseases of the Colon and Rectum·UNKNOWN 2015 European Society of Coloproctology Collaborating Group
Feb 15, 2021·Updates in Surgery·Tommaso GiulianiClaudio Bassi
Jul 1, 2020·The Journal of Surgical Research·Naomi-Liza DenningAaron M Lipskar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.