Risk factors for anastomotic leakage after resection of rectal cancer

The British Journal of Surgery
E RullierM Parneix

Abstract

The most important surgical complication following rectal resection with anastomosis is symptomatic anastomotic leakage, which is associated with a 6-22 per cent mortality rate. The aim of this retrospective study was to evaluate the risk factors for clinical anastomotic leakage after anterior resection for cancer of the rectum. From 1980 to 1995, 272 consecutive anterior resections for rectal cancer were performed by the same surgical team; 131 anastomoses were situated 5 cm or less from the anal verge. The associations between clinical anastomotic leakage and 19 patient-, tumour-, surgical-, and treatment-related variables were studied by univariate and multivariate analysis. The rate of clinical anastomotic leakage was 12 per cent (32 of 272). Multivariate analysis of the overall population showed that only male sex and level of anastomosis were independent factors for development of anastomotic leakage. The risk of leakage was 6.5 times higher for anastomoses situated less than 5 cm from the anal verge than for those situated above 5 cm; it was 2.7 times higher for men than for women. In a second analysis of low anastomoses (5 cm or less from the anal verge; n = 131), obesity was statistically associated with leakage. A pro...Continue Reading

References

Sep 1, 1978·Diseases of the Colon and Rectum·V W Fazio
Apr 1, 1992·The British Journal of Surgery·K MealyJ Hyland
Feb 1, 1992·International Journal of Colorectal Disease·F BozzettiL Gennari
Feb 1, 1991·The British Journal of Surgery·N D KaranjiaR J Heald
Oct 1, 1990·The British Journal of Surgery·J D BeardN W Everson
Feb 1, 1990·International Journal of Colorectal Disease·J R Tuson, W G Everett
Feb 1, 1990·The British Journal of Surgery·J R Novell, A A Lewis
Aug 1, 1985·The British Journal of Surgery·F P McGinnF J Brunton
May 1, 1973·Annals of Surgery·T R SchrockJ E Dunphy
Feb 1, 1970·The British Journal of Surgery·J C GoligherF T De Dombal
Apr 1, 1984·American Journal of Surgery·L P FieldingL Blesovsky
May 1, 1981·The British Journal of Surgery·R J Heald, R J Leicester
Aug 9, 1980·British Medical Journal·L P FieldingG Kearney
Oct 1, 1995·The British Journal of Surgery·J A GrabhamR H Lane
Dec 1, 1995·Diseases of the Colon and Rectum·A LaxamanaR S McLeod
Aug 1, 1994·The British Journal of Surgery·N D KaranjiaR J Heald
Jul 1, 1993·The British Journal of Surgery·H P RedmondJ M Deasy
Jan 1, 1996·Diseases of the Colon and Rectum·O HansenW Stock
Jan 1, 1996·The British Journal of Surgery·B MannW Stremmel
Apr 1, 1997·The British Journal of Surgery·E RullierM Parneix

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Citations

Apr 11, 2000·Seminars in Surgical Oncology·B Moran, R Heald
Jan 11, 2007·Diseases of the Colon and Rectum·D J BrennanP Ronan O'Connell
May 2, 2001·Diseases of the Colon and Rectum·M KillingbackO F Dent
Aug 19, 2004·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S Willis, M Stumpf
Dec 8, 2004·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M StumpfP R Mertens
Nov 5, 2004·International Journal of Colorectal Disease·Richard John EnglandShwan Niazi Amin
Jan 30, 2007·International Journal of Colorectal Disease·Martin KruschewskiHeinz J Buhr
Jun 7, 2007·International Journal of Colorectal Disease·Gabriele ValentiGiovanni Torino
Sep 5, 2007·International Journal of Colorectal Disease·B LefebureF Michot
Nov 24, 2007·International Journal of Colorectal Disease·Nicolas C BuchsPhilippe Morel
Dec 12, 2007·International Journal of Colorectal Disease·K HorisbergerF Willeke
Sep 3, 2008·International Journal of Colorectal Disease·Xiang-Yong HaoHong-Ling Li
Feb 18, 2009·International Journal of Colorectal Disease·Andre ChowSanjay Purkayastha
Mar 21, 2009·International Journal of Colorectal Disease·Niels KomenJohan F Lange
Aug 6, 2009·International Journal of Colorectal Disease·Olivier BrehantJean-Marc Regimbeau
Jan 13, 2010·International Journal of Colorectal Disease·Ki-Beom BaeKwan-Hee Hong
Feb 4, 2010·International Journal of Colorectal Disease·Angela FischerFranc H Hetzer
Feb 24, 2010·International Journal of Colorectal Disease·Aneel BhanguRaju Tiramula
Apr 14, 2010·International Journal of Colorectal Disease·Ui Sup ShinJin Cheon Kim
Jun 22, 2010·International Journal of Colorectal Disease·Laura A HealyJohn V Reynolds
Aug 6, 2010·International Journal of Colorectal Disease·Akio ShiomiYoshihiro Moriya
Aug 11, 2010·International Journal of Colorectal Disease·Andreas VolkHans Detlev Saeger
Dec 31, 2010·International Journal of Colorectal Disease·Elisabeth LippertFrank Kullmann
Sep 13, 2011·International Journal of Colorectal Disease·Joakim FolkessonLars Påhlman
May 12, 2012·International Journal of Colorectal Disease·Oscar ÅkessonPamela Buchwald
Feb 6, 2013·International Journal of Colorectal Disease·K Adams, S Papagrigoriadis
Apr 12, 2011·Langenbeck's Archives of Surgery·Nino GullàGiuseppe Noya
Oct 19, 2007·Surgical Endoscopy·Pascal BucherPhilippe Morel
Sep 20, 2008·Surgical Endoscopy·Nobuyoshi MiyajimaUNKNOWN Japan Society of Laparoscopic Colorectal Surgery
Oct 25, 2012·Surgical Endoscopy·Gian Luca Baiocchi, Carlo Augusto Sartori
Jul 22, 2005·Surgery Today·Eline A VlotJoost M Klaase

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