PMID: 8950773Nov 1, 1996Paper

Risk factors for bleeding during treatment of acute venous thromboembolism

Thrombosis and Haemostasis
J P WesterJ D Banga

Abstract

Identification of risk factors for bleeding and prospective evaluation of two bleeding risk scores in the treatment of acute venous thromboembolism. Secondary analysis of a prospective, randomized, assessorblind, multicenter clinical trial. One university and 2 regional teaching hospitals. 188 patients treated with heparin or danaparoid for acute venous thromboembolism. The presenting clinical features, the doses of the drugs, and the anticoagulant responses were analyzed using univariate and multivariate logistic regression analysis in order to evaluate prognostic factors for bleeding. In addition, the recently developed Utrecht bleeding risk score and Landefeld bleeding risk index were evaluated prospectively. Major bleeding occurred in 4 patients (2.1%) and minor bleeding in 101 patients (53.7%). For all (major and minor combined) bleeding, body surface area < or = 2 m2 (odds ratio 2.3, 95% CI 1.2-4.4; p = 0.01), and malignancy (odds ratio 2.4, 95% CI 1.1-4.9; p = 0.02) were confirmed to be independent risk factors. An increased treatment-related risk of bleeding was observed in patients treated with high doses of heparin, independent of the concomitant activated partial thromboplastin time ratios. Both bleeding risk scores ...Continue Reading

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