PMID: 37169May 15, 1979

Risk factors for cancer of the testis in young men

International Journal of Cancer. Journal International Du Cancer
B E HendersonM C Pike

Abstract

An individual matched case-control study of testis cancer in 131 men under age 40 was conducted to investigate antecedent risk factors including events during prenatal life. Ten patients were born with an undescended testis compared to only two controls (p less equal to 0.02), a previously reported risk factor. Two new risk factors were uncovered: six patients-mothers received hormones during the index pregnancy compared to only one control-mother, and eight patient-mothers and two control-mothers reported excessive nausea as a complication of the index pregnancy. A hypothesis linking these three factors is presented: viz, that a major risk factor for testis cancer is a relative excess of certain hormones (in particular estrogen) at the time of differentiation of the testes.

References

May 3, 1996·International Journal of Cancer. Journal International Du Cancer·H Møller, N E Skakkebaek
Jun 11, 1997·International Journal of Cancer. Journal International Du Cancer·E PetridouD Trichopoulos
Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·L HardellM Fredrikson
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·H K WeirL Sugar
Jul 1, 1995·American Journal of Industrial Medicine·W RhombergB Schneider
Jan 1, 1994·The Prostate·R SanttiJ A McLachlan
Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·R MalmiK O Söderström
Jul 29, 2005·Cancer Causes & Control : CCC·V Paul Doria-RoseNoel S Weiss
Apr 17, 2008·Cancer Causes & Control : CCC·Jonine D FigueroaKatherine A McGlynn
Feb 22, 2011·Cancer Causes & Control : CCC·Britton TrabertKatherine A McGlynn
Jun 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J MillischerG Hodson-Walker
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Q HattonS B Kaye
Jun 1, 1990·Mayo Clinic Proceedings·S R PatelR L Richardson
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Alison VennRobert McLachlan
Aug 1, 2011·Journal of Developmental Origins of Health and Disease·P M MullinM S Fejzo
Oct 13, 2006·Nature Clinical Practice. Urology·Freddie BrayH Møller
Jul 25, 2000·International Journal of Andrology·J T SeoM S Lee
Sep 25, 2002·Journal of Internal Medicine·H KuperH-O Adami
Jul 10, 1980·The New England Journal of Medicine·J E LoughlinA S Morrison
Jan 1, 1995·Archives of Environmental Health·Z F ZhangJ R Marshall
Jul 31, 2001·Family Practice·A Khadra, P Oakeshott
May 16, 2009·Human Reproduction·O Akre, Lorenzo Richiardi
Nov 26, 2009·Human Reproduction·Michael Joffe
Jul 28, 2010·International Journal of Epidemiology·Michael B CookKatherine A McGlynn
Jun 4, 1997·Journal of the National Cancer Institute·B E HendersonL Bernstein
Apr 5, 2001·Journal of the National Cancer Institute·W C StrohsnitterE E Hatch
Oct 6, 2005·Journal of the National Cancer Institute·Richard M MartinGeorge Davey Smith
May 1, 2008·Journal of the National Cancer Institute·Katherine A McGlynnRalph L Erickson
Jul 1, 1994·Paediatric and Perinatal Epidemiology·J TrédanielA Hirsch
Jan 1, 1996·Paediatric and Perinatal Epidemiology·G S Berkowitz, R H Lapinski
Mar 17, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S H Swan
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Ekbom, O Akre
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Møller
Mar 21, 1992·BMJ : British Medical Journal·R R West
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Feb 26, 1999·BMJ : British Medical Journal·H Møller, N E Skakkebaek
Sep 29, 2000·BMJ : British Medical Journal·R JacobsenH Moller
Sep 1, 1983·Journal of Epidemiology and Community Health·A J SwerdlowP G Smith
Mar 1, 1987·Journal of Epidemiology and Community Health·L Le Marchand, L N Kolonel
Jun 1, 1987·Journal of Epidemiology and Community Health·M H BurtonP R Raggatt
Dec 1, 1987·Journal of Epidemiology and Community Health·L M BrownR N Hoover
Dec 1, 1989·Journal of Epidemiology and Community Health·M HjertkvistA Bergh

Citations

Apr 1, 1976·Journal of the National Cancer Institute·A S Morrison
Sep 7, 1978·The New England Journal of Medicine·K J Rothman, C Louik
Feb 1, 1977·The Journal of Urology·M D CoscroveB E Henderson
Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·H M Hayes, T W Pendergrass
Nov 1, 1975·Public Health·S Hodgson
Sep 1, 1968·American Journal of Obstetrics and Gynecology·D V Fairweather
Sep 24, 1959·The New England Journal of Medicine·N M KAPLAN

Related Concepts

Undescended Testis (Body Structure)
Fetal Structures
Cryptorchidism
Estradiol Congeners
Cell Differentiation Process
Prenatal brand of multivitamin
Pregnancy Complications
Inferior Colliculus
Testis
Complication

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