Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections and Outcomes

Infection and Drug Resistance
Youhua YuanEnguo Fan

Abstract

The incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections (BSIs) is increasing globally; however, little has been reported on the risk factors and outcomes of CRKP BSIs in central China. This study aimed to determine the clinical risk factors for CRKP BSIs and the outcomes of CRKP BSIs. We performed a case-control study of 239 patients with K. pneumoniae BSIs who were treated at Henan Provincial People's Hospital between July 2017 and July 2018. The cases (n=98, 41%) had CRKP BSIs, and the controls (n=141, 59%) had non-carbapenem-resistant K. pneumoniae (non-CRKP) BSIs. Antimicrobial sensitivity was determined using automated broth microdilution and an agar disk diffusion method. Data were obtained from clinical and laboratory records. Multivariate logistic regression and Pearson chi-square tests were used to identify clinical factors and outcomes associated with carbapenem resistance. Risk factors for carbapenem resistance included recent carbapenem use (odds ratio [OR]: 9.98, 95% confidence interval [CI]: 5.2-17.1, P<0.001), invasive procedures (OR: 11.1, 95% CI: 3.3-37.7, P<0.001), and pre-existing diseases of the digestive system (OR: 8.22, 95% CI: 1.73-39.2, P=0.008). Treatment failure was m...Continue Reading

Software Mentioned

GraphPad
SPSS
Prism7

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Related Papers

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Yee Gyung KwakYang Soo Kim
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Khetam HusseinRenato Finkelstein
© 2021 Meta ULC. All rights reserved