Risk factors for cardiovascular disease and mortality events in adults with type 2 diabetes - a 10-year follow-up: Tehran Lipid and Glucose Study

Diabetes/metabolism Research and Reviews
Sheila AfsharianFarzad Hadaegh

Abstract

To identify risk factors for cardiovascular disease (CVD) and mortality events in patients with type 2 diabetes and to calculate their population attributable fraction among a representative Iranian population. A total of 1198 patients with type 2 diabetes (504 men and 694 women), aged ≥30 years, without prevalent CVD, with a median follow-up of 10 years were included in current study. To examine the association between risk factors and their outcomes, multivariate sex-adjusted Cox proportional hazard regression models were used. During the study, 281 and 172 participants experienced CVD and all-cause mortality events, respectively. Regarding CVD events, fasting plasma glucose (FPG) level of 7.22-<10 mmol/L [hazard ratio (HR): 1.46, 95% CI 1.12-1.96], FPG level ≥10 mmol/L (HR 2.04, 1.53-2.72), hypertension (HR 1.65, 1.28-2.13), hypercholesterolaemia (HR 1.96, 1.40-2.75) and high waist to hip ratio (HR 1.30, 0.99-1.70; p = 0.051) were significant predictors, and corresponding population attributable fractions were 9.76, 17.84, 23.26, 41.63 and 14.76%, respectively. Considering all-cause mortality events, hypertension (HR 1.70, 1.23-2.36), FPG level ≥10 mmol/L (HR 2.31, 1.55-3.20) and smoking (HR 1.45, 1.03-2.04) were significant...Continue Reading

References

Nov 1, 1985·American Journal of Epidemiology·P BruzziC Schairer
Aug 3, 2000·The American Journal of Cardiology·J P SinghD Levy
Mar 28, 2003·American Journal of Public Health·Kimberly S H YarnallJ Lloyd Michener
Apr 21, 2004·Annals of Internal Medicine·Sandeep VijanUNKNOWN American College of Physicians
Mar 2, 2005·Archives of Internal Medicine·Sundar NatarajanStuart R Lipsitz
Feb 15, 2008·Diabetes Care·Cristina BianchiStefano Del Prato
Feb 8, 2008·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Jun 10, 2008·Diabetes Care·David M NathanUNKNOWN A1c-Derived Average Glucose Study Group
Oct 4, 2008·Epidemiologic Perspectives & Innovations : EP+I·Craig A Mason, Shihfen Tu
Jan 27, 2009·Trials·Fereidoun AziziUNKNOWN Tehran Lipid and Glucose Study Group
Jul 25, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tung Wai AuyeungJean Woo
Sep 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F HadaeghF Azizi
May 22, 2010·Lipids in Health and Disease·Yunqin ChenHaozhu Chen
Feb 25, 2011·The New England Journal of Medicine·Wei ZhengJohn D Potter
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Aug 9, 2012·JAMA : the Journal of the American Medical Association·Mercedes R CarnethonAlan R Dyer
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Katherine M FlegalBarry I Graubard
Jun 21, 2013·The Journal of Cardiovascular Nursing·Mariam KashaniMary Terhaar
Nov 19, 2013·JAMA : the Journal of the American Medical Association·Seth S MartinSteven R Jones
Jan 17, 2014·The New England Journal of Medicine·Deirdre K TobiasFrank B Hu
Feb 12, 2014·Diabetes Care·Nancy WeiDavid M Nathan
Feb 27, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Joshua J Joseph, Sherita Hill Golden
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Paul Z ZimmetJonathan E Shaw
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Sep 5, 2014·Diabetologia·Sabita S Soedamah-MuthuTrevor J Orchard
Dec 3, 2014·The Medical Clinics of North America·Silvio Inzucchi, Sachin Majumdar
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
Feb 11, 2015·JAMA : the Journal of the American Medical Association·Connor A EmdinAnushka Patel
Oct 27, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·C HeroK Eeg-Olofsson

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Citations

Aug 4, 2016·Substance Use & Misuse·Hélène Donnadieu-RigolePascal Perney
Aug 17, 2016·International Journal of Molecular Sciences·Thiago Melo Costa PereiraElisardo Corral Vasquez
Apr 28, 2017·European Journal of Preventive Cardiology·Nahid Hashemi MadaniAmeneh Ebrahimi Valojerdi
Dec 2, 2017·Journal of Diabetes Investigation·Satoshi IdaRyutaro Kaneko
Dec 26, 2018·International Journal of Endocrinology and Metabolism·Azra RamezankhaniFarzad Hadaegh
Mar 20, 2019·Current Cardiology Reports·Caroline Holm NørgaardNathan D Wong
Dec 26, 2018·International Journal of Endocrinology and Metabolism·Donna ParizadehFarzad Hadaegh
Aug 8, 2021·Diabetes Research and Clinical Practice·Cheng-Chieh LinTsai-Chung Li

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