PMID: 8938217Jan 1, 1996Paper

Risk factors for central nervous system involvement in non-Hodgkins-lymphoma--a multivariate analysis

Acta Oncologica
N KeldsenK Thorling

Abstract

A consecutive cohort of patients with NHL was examined to identify the factors predictive of CNS-involvement with Cox's proportional hazards model in a multivariate analysis. Twenty-seven cases of CNS-involvement were found among 498 patients with NHL. Only 3 of 96 patients with low-grade lymphomas had CNS involvement, all occurring after transformation into high-grade lymphoma. In univariate analysis of 402 patients with intermediate or high-grade lymphoma, lymphoblastic histology (including Burkitt's lymphoma), age <35 years, B-symptoms, stage IV disease, testis involvement and bone marrow involvement were found to be statistically significant risk factors. Lymphoblastic histology was found to be strongly correlated to age younger than 35 years. In the multivariate analysis only lymphoblastic histology, stage IV disease and B-symptoms were found to be significantly associated with CNS involvement. It is concluded that CNS prophylaxis should be considered in all patients with lymphoblastic histology and in patients with stage IV B lymphomas other than those of low-grade types.

References

Dec 1, 1991·American Journal of Clinical Oncology·R M BashirJ O Armitage
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T B HaddyI T Magrath
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·X TroussardJ P Vernant
Apr 1, 1989·European Journal of Cancer & Clinical Oncology·R H LiangJ S Shum
Jul 1, 1988·Cancer·S M BentzenC Arnoldi
Feb 1, 1985·Australian and New Zealand Journal of Medicine·M M WolfJ P Madigan
Nov 1, 1985·Scandinavian Journal of Haematology·J ErsbøllN I Nissen
Feb 1, 1980·Cancer·L J LevittW C Moloney

❮ Previous
Next ❯

Citations

Sep 1, 2006·Current Treatment Options in Neurology·Janet L Franklin, Jonathan Finlay
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A C McDonaldR P Rampling
May 31, 2002·Internal Medicine Journal·Jeremy Wellwood, K Taylor
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HollenderH Holte
Apr 15, 2006·The Cancer Journal·Joachim M Baehring, Fred H Hochberg
Dec 25, 2008·Current Opinion in Oncology·Hwee Yong LimMichael J Glantz
Aug 24, 2006·International Journal of Hematology·Naoto TomitaYoshiaki Ishigatsubo
Dec 17, 2004·Neurologia Medico-chirurgica·Kenichiro OnoTadashi Inohara
Apr 5, 2014·Critical Reviews in Oncology/hematology·Abhimanyu GhoseTahir Latif
Jan 17, 2012·Blood Reviews·Tali Siegal, Neta Goldschmidt
Aug 11, 2010·Critical Reviews in Oncology/hematology·Fabio CanovaSavina Maria Luciana Aversa
Oct 22, 2008·Medicina clínica·Juan-Manuel SanchoUNKNOWN investigators of QUIT Study (PETHEMA, GELTAMO and GOTEL Groups)
Oct 4, 2005·British Journal of Haematology·C W CheungK M Ardeshna
Sep 22, 2005·British Journal of Haematology·Andrew McMillan
Sep 17, 2013·British Journal of Haematology·Andrew McMillanUNKNOWN British Committee for Standards in Haematology
Aug 4, 2006·Blood Reviews·Quentin A Hill, Roger G Owen
Aug 9, 2005·Hematology/oncology Clinics of North America·Philip Bierman, Pierre Giglio
Jul 5, 2016·Clinical Lymphoma, Myeloma & Leukemia·Megan M HerrDavid Q Rich
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra QuijanoUNKNOWN Spanish Group for the Study of CNS Disease in NHL
Mar 1, 2006·Expert Review of Anticancer Therapy·Danish MazharMark Bower
Sep 5, 2008·Current Protocols in Cytometry·Jaco KraanWyndham Wilson
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C BishopP C Elwood
Dec 19, 2015·Blood·Jennifer BrudnoKieron Dunleavy
Jun 13, 2016·Journal of Neuro-oncology·Megan M HerrDavid Q Rich
Mar 13, 2021·Pharmacological Reports : PR·Kamal S AbdelrahmanMohamed Abdel-Aziz

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.