Risk factors for chronic lung disease and asthma differ among children born extremely preterm.

Pediatric Pulmonology
Wesley M JacksonAlan Leviton

Abstract

To evaluate the hypothesis that chronic lung disease of prematurity (CLD) is a risk factor for asthma in children born extremely preterm, and the hypothesis that the risk factors for CLD are similar to those for asthma. A retrospective analysis was performed using data collected prospectively from 882 children born before the 28th week of gestation between 2002 and 2004 who returned for follow-up at ages 12 and 24 months and 10 years. We created time-oriented logistic regression models to compare risk factors for CLD, defined as need for supplemental oxygen at 36 weeks postmenstrual age, and parent-reported asthma at 10 years of age. CLD diagnosed during neonatal admission was associated with bronchodilator use at 12 months and 24 months (P < 0.001), but not with an asthma diagnosis at 10 years (Odds Ratio 1.3; 95% confidence interval 0.98-1.8). While risk factors for CLD include lower gestational age (OR 2.7; 1.5-4.7) and fetal growth restriction (OR 2.3; 1.4-3.7), risk factors for asthma include mother's eligibility for public insurance (Medicaid) (OR 1.8; 1.1-2.8), and higher weight gain velocity during the first year (OR 1.5; 1.02-2.2) and between the 2nd and 10th year (OR 1.7; 1.2-2.4). Among children born extremely preter...Continue Reading

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Apr 21, 2019·Pediatric Research·Jacqueline T BangmaUNKNOWN ELGAN Investigators
Apr 10, 2020·Journal of Paediatrics and Child Health·Stuart HaggieDominic A Fitzgerald
Feb 28, 2019·Pediatric Pulmonology·Richard L Auten
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