PMID: 8971889Dec 1, 1996Paper

Risk factors for chronic rejection in pediatric renal allograft recipients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
C GuyotJ L André

Abstract

To determine the risk factors predictive of graft loss from chronic rejection in pediatric renal allograft recipients, we reviewed the collaborative study database of the Société de Néphrologie Pédiatrique which registered 314 grafts from January 1987 to December 1991. Of the 289 grafts analyzed, 71 failed during follow-up, chronic rejection being the most common cause of graft loss (35%). The clinical features of the chronic rejection group (n = 25) were compared with those of the group without failure (n = 218). The variables tested by monovariate analysis were cyclosporine dose at 1 year, donor type, donor and recipient age, and acute rejection episodes. The incidence of graft loss due to chronic rejection was 4% (4/109) in patients who had no acute rejection and 16% (21/134) in those with at least one acute rejection episode (P = 0.002). Donor age (< or = 5 years) was a risk factor for chronic rejection (P = 0.024). Recipient age and donor type were not significantly different between the chronic rejection group and the control group. Using time-dependent covariates, the risk factors were an acute rejection episode (P = 0.003) and low cyclosporine doses at 1 year (P = 0.02). We conclude that acute rejection and low cyclospo...Continue Reading

Citations

Jun 26, 1998·Transplant Immunology·A J Matas
Jul 11, 2003·The New England Journal of Medicine·Minnie SarwalOscar Salvatierra
Aug 19, 2003·Transplantation·Jose R TorrealbaStuart J Knechtle
Feb 11, 2010·Transplantation·Allison B DartPatricia E Birk
Aug 10, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·G FillerI Mai
Sep 4, 2015·Pediatric Transplantation·Ashley E WaltherJaimie D Nathan
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ebru SerinsözMichael Mengel
Jan 9, 2004·Pediatric Clinics of North America·Mark R Benfield
Apr 29, 1998·Annals of Medicine·J LaineC Holmberg
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerM H Sayegh
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Amir TejaniUNKNOWN North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)
Mar 29, 2001·Pediatric Transplantation·A Tejani
Feb 10, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·James McCaffrey, Mohan Shenoy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
P E BirkB M Chavers
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
P NiaudetL Chatenoud
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D J Norman, M R Leone
© 2021 Meta ULC. All rights reserved