Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study

Gastroenterology Report
Xianrui WuPing Lan

Abstract

This study sought to evaluate the risk factors for the development of colitis-associated neoplasia (CAN) in Chinese patients with inflammatory bowel disease (IBD). IBD patients who developed CAN between 1999 and 2016 were identified from eight medical centers. In addition to initial pathology evaluation, a CAN diagnosis was confirmed by two expert pathologists. Patients with CAN (n = 29) were compared with non-CAN controls (n = 87). Matching was performed for gender and IBD type with a ratio of three controls to one subject. Of the 29 patients with CAN, 8 (27.6%) had colorectal cancer (CRC), 20 (69.0%) had a final diagnosis of low-grade dysplasia and 1 (3.4%) had high-grade dysplasia. Multivariate analysis revealed that an older age at the time of IBD diagnosis and a longer IBD duration were independent risk factors for the development of CAN, with odds ratios of 1.09 [95% confidence interval (CI): 1.04-1.14, P < 0.001] and 1.14 (95% CI: 1.03-1.27, P = 0.013), respectively. Comparison between IBD patients with CRC and those with dysplasia indicated that the former were older at the time of IBD diagnosis (P = 0.012) and had longer IBD durations (P = 0.019). Older age at the time of IBD diagnosis and longer IBD duration were foun...Continue Reading

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Citations

Jul 18, 2019·Journal of Crohn's & Colitis·Mark Löwenberg, Manon Van Der Vlugt
Jun 12, 2020·Therapeutic Advances in Gastroenterology·Jordan E Axelrad, Shailja C Shah
May 25, 2021·Gastroenterology Report·Yumo XieYanxin Luo

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Software Mentioned

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