Abstract
The aim of this study was to clarify whether the clinical, laboratory and genetic aspects of sickle cell disease (SCD) influence the occurrence of vessel alterations in the conjunctiva and retina. A total of 102 SCD patients underwent biomicroscopical and retinal examination, in addition to evaluations of haemoglobin (Hb) and haematocrit (Ht) levels, fetal haemoglobin (HbF) estimations, serum creatinine and albuminuria levels, glomerular filtration rate (GFR) values, phenotypes, beta-globin gene haplotypes and alpha-thalassaemia. The relationship between ocular vessel alterations and clinical, laboratory and genetic features were evaluated using chi-squared or Fisher tests and logistic regression analysis. In 13 patients on enalapril treatment, a second ophthalmological evaluation was performed after a 12-month period to evaluate the longitudinal effect of the drug on ocular vessels. Conjunctival vessel alteration (CVA) was not influenced by age, gender, HbF estimation, serum creatinine and albuminuria levels, GFR values, beta-globin gene haplotypes or alpha-thalassaemia. However, increased frequencies of CVA were found in patients with Hb </= 9.0 g/dl, Ht </= 26.7% and sickle cell anaemia (SS) phenotype. Retinal vessel alterat...Continue Reading
References
Oct 1, 1990·Acta Ophthalmologica·W C SiqueiraM A Zago
Mar 1, 1990·The British Journal of Ophthalmology·P D FoxG R Serjeant
Sep 1, 1989·American Journal of Hematology·M SuttonR L Nagel
Jan 1, 1988·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M T BonanomiJ T de Araújo
Aug 1, 1985·The British Journal of Ophthalmology·M S RoyA N Schechter
Apr 1, 1972·American Journal of Ophthalmology·P I Condon, G R Serjeant
Apr 1, 1971·Archives of Ophthalmology·M F Goldberg
Jan 1, 1981·The British Journal of Ophthalmology·R J HayesG R Serjeant
Jul 1, 1983·Archives of Ophthalmology·M L AisenE M Chester
Jun 1, 1980·The British Journal of Ophthalmology·P I Condon, G R Serjeant
May 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·M H Steinberg
May 1, 1995·The American Journal of Medicine·R Y Aoki, S T Saad
Sep 1, 1994·The British Journal of Ophthalmology·A D PenmanA C Bird
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Oct 13, 1994·The New England Journal of Medicine·G P RodgersM J Podgor
Jan 1, 1994·American Journal of Hematology·F F CostaM L Nascimento
Jan 1, 1993·British Journal of Haematology·C DodéJ Rochette
Jun 1, 1993·Ophthalmology·K J CruickshanksS E Moss
Oct 1, 1996·American Journal of Hematology·M S FigueiredoF F Costa
May 12, 1998·The American Journal of Medicine·L FoucanR L Salmi
Sep 2, 1998·American Journal of Hematology·K LeeF Galactéros
Feb 26, 2000·Ophthalmology·A R KentR L Hebert
Jun 30, 2000·American Journal of Human Genetics·J Alves-SilvaV F Prado
Nov 25, 2000·American Journal of Human Genetics·D R Carvalho-SilvaS D Pena
May 1, 1954·American Journal of Clinical Pathology·R P MACFATEJ A COOPER
Jul 1, 1961·Archives of Ophthalmology·D PATON
Nov 1, 1962·Archives of Ophthalmology·D PATON
Citations
Aug 28, 2012·TheScientificWorldJournal·Samir K BallasPunam Malik
May 11, 2010·Survey of Ophthalmology·Mohammed ElagouzSobha Sivaprasad
May 10, 2013·American Journal of Hematology·Justin WanekMahnaz Shahidi
Nov 29, 2014·Acta Ophthalmologica·Ali Kord ValeshabadMahnaz Shahidi
Dec 10, 2015·São Paulo Medical Journal = Revista Paulista De Medicina·Aline Menezes CarlosHelio Moraes-Souza
Feb 8, 2014·Cornea·Sunita ChaurasiaArchana Bhargava
Mar 19, 2019·Medical Physics·Wenkun ZhangBin Yan
Aug 8, 2020·Ophthalmic Epidemiology·Saif Aldeen AlRyalatMouna Al Saad
Mar 1, 2018·Revista da Associação Médica Brasileira·Marina Viegas Moura Rezende RibeiroÊurica Adélia Nogueira Ribeiro