Risk Factors for De Novo Malignancies in Women After Kidney Transplantation: A Multicenter Transversal Study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Samir HelmyChristoph Grimm

Abstract

Transplantation results in a 5-time elevated risk for a variety of malignancies (Kaposi sarcoma, skin, liver, lung, gastrointestinal cancer). A patient's risk for malignancies could be of particular interest for the follow-up programs of patients and risk adaption after kidney transplantation. The aim of this study was to identify independent risk factors for de novo malignancies in women after renal transplantation. This is a multicenter transversal study, conducted at the Medical University of Vienna and Hospital Rudolfstiftung, Vienna, Austria. We included female kidney graft recipients who were transplanted between 1980 and 2012 and followed-up at our institutions (N = 280). Clinical data of patients were extracted from hospital charts and electronic patient files. Patients were interviewed using a standardized questionnaire regarding their medical history, history of transplantation, and malignant diseases. Detailed information about present and past immunosuppressive regimens, rejection episodes and therapies, renal graft function, and information about primary disease was obtained. Diagnostic work-up and/or surgical exploration was performed if any presence of malignancy was suspected during routine follow-up. Histologic...Continue Reading

References

Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A D Howard
Apr 29, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Friedrich K PortRobert A Wolfe
Dec 24, 2004·The New England Journal of Medicine·Philip F Halloran
Oct 28, 2005·Transplantation·Joseph F BuellE Steve Woodle
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Claire M VajdicAndrew E Grulich
Oct 2, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Kim A P MeeuwisJoanne A de Hullu
Nov 3, 2011·JAMA : the Journal of the American Medical Association·Eric A EngelsMonica Lin
Mar 20, 2012·Critical Reviews in Oncology/hematology·F HintenJ A de Hullu
Oct 16, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pierluca PiselliUNKNOWN Immunosuppression and Cancer Study Group
Apr 30, 2013·Transplantation Proceedings·A RochaA C Henriques
Feb 17, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A McCaughan, A E Courtney

❮ Previous
Next ❯

Citations

May 30, 2019·Oncotarget·Anna BuxedaJulio Pascual
Oct 11, 2017·The British Journal of Dermatology·M M MadeleineUNKNOWN the Keratinocyte Carcinoma Consortium (KeraCon) Immunosuppression Working Group
May 22, 2021·Transplantation Reviews·Anna BuxedaJulio Pascual

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Samir HelmyChristoph Grimm
Transplant International : Official Journal of the European Society for Organ Transplantation
Jeong-Kye HwangJi-Il Kim
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Sanjiv SaigalJohn O'Grady
Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Jai PrakashKishan Aralapuram
© 2022 Meta ULC. All rights reserved