Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
S J KimJ H Lee

Abstract

SETTING The long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described. To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease over a 5-year follow-up period. Clinical and laboratory data of 67 patients with nodular bronchiectatic MAC lung disease were collected. Chest computerised tomographic images were used to count the number of lung segments involved at diagnosis and measure subcutaneous fat thickness during follow-up. The 34 patients who showed deterioration had significantly lower body mass index (BMI) (P = 0.004) and % predicted forced vital capacity (P = 0.032), higher numbers of lung segments involved (P < 0.001) and MAC-positive sputum cultures (P = 0.028), and thinner chest subcutaneous fat during follow-up (P < 0.001) than patients without deterioration. In particular, patients with both BMI <21.0 kg/m(2) and more than four lung segments involved had a 240-fold increased risk of deterioration (P < 0.001). Patients with poor nutritional status and extensive lung involvement tend to experience deterioration of nodular bronchiectatic MAC lung disease.

Citations

Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takanori AsakuraMotofumi Ouchi
May 26, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheng-Wei PanWei-Juin Su
Mar 10, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun Jung YoonWon-Jung Koh
Mar 10, 2017·The European Respiratory Journal·Ji An HwangTae Sun Shim
Dec 24, 2018·Tuberculosis and Respiratory Diseases·Yong Soo KwonCharles L Daley
Aug 8, 2020·PloS One·Norio KodakaHiroto Matsuse
Oct 28, 2020·The Indian Journal of Medical Research·Surendra K Sharma, Vishwanath Upadhyay
May 27, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Kelly M PenningtonZelalem Temesgen
Jun 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Norio KodakaHiroto Matsuse

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