Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Selim CorbaciogluMohamad Mohty

Abstract

Veno-occlusive disease, also known as sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening complication of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) most commonly associated with high-intensity chemotherapies. The development of VOD/SOS may be rapid and unpredictable, and the importance of identifying risk factors to facilitate prompt diagnosis and timely treatment has become increasingly recognized. The reporting of new retrospective study data for adults and children and the emergence of novel anticancer therapies that may increase the risk of VOD/SOD also necessitate updates on risk factors, as provided in this review. The latest studies reporting VOD/SOS risk factors support previously published data, although the importance of patient-related factors, such as acute kidney injury, increased international normalized ratio, female sex (in children), and platelet refractoriness, is given greater emphasis in the recent data. Non-transplantation-related chemotherapies associated with increased risk for VOD/SOS include oxaliplatin and 5-fluorouracil chemotherapies. The novel antibody drug conjugates gemtuzumab ozogamicin and inotuzumab ozogamicin are now reported in product la...Continue Reading

Citations

May 20, 2020·Leukemia & Lymphoma·Jill FulcherMitchell Sabloff
Sep 30, 2020·Expert Opinion on Biological Therapy·Benjamin H GoldensonEdward D Ball
May 24, 2020·Current Hematologic Malignancy Reports·Alexander Gavralidis, Andrew M Brunner
Jul 2, 2020·Current Hematologic Malignancy Reports·Joselle Cook, Mark Litzow
Dec 15, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Amanda DeMauro RenaghanMitchell Howard Rosner
Apr 23, 2020·Frontiers in Immunology·Francesca BonifaziAntonio Colecchia
May 1, 2021·Journal of Personalized Medicine·Nicolas WaespeMarc Ansari
Jul 6, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrew P LangeFredric D Gordon

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