Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease.

The Journal of Pediatrics
Kathrin BurgmaierARegPKD consortium

Abstract

To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. Thirty-six out of 385 children (9.4%) commenced dialysis in the first year of life. According to multivariable Cox regression analysis, the presence of oligohydramnios or anhydramnios, prenatal kidney enlargement, a low Apgar score, and the need for postnatal breathing support were independently associated with an increased hazard ratio for requiring dialysis within the first year of life. The increased risk associated with Apgar score and perinatal assisted breathing was time-dependent and vanished after 5 and 8 months of life, respectively. The predicted probabilities for early dialysis varied from 1.5% (95% CI, 0.5%-4.1%) for patients with ARPKD with no prenatal sonographic abnormalities to 32.3% (95% CI, 22.2%-44.5%) in cases of documented oligohydramnios or anhydramnios, renal cysts, and enlarged kidneys. This study, ...Continue Reading

Citations

Sep 29, 2020·Journal of Neonatal-perinatal Medicine·R RainaC Bergmann
Jan 22, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eric G Benz, Erum A Hartung
Feb 9, 2021·Journal of Pediatric Genetics·Dorota WicherIrena Jankowska
Feb 18, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Max Christoph Liebau
Jul 3, 2021·International Journal of Molecular Sciences·Adrian CordidoMiguel A Garcia-Gonzalez
Jul 13, 2021·Frontiers in Genetics·Jonathan de FalloisJan Halbritter
Aug 14, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte GimpelFranz Schaefer
Nov 6, 2021·Scientific Reports·Kathrin BurgmaierUNKNOWN ARegPKD Consortium
Dec 10, 2021·Molecular and Cellular Pediatrics·Max Christoph Liebau, Djalila Mekahli

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