Risk Factors for Future Scleroderma Renal Crisis at Systemic Sclerosis Diagnosis

The Journal of Rheumatology
Sarah M GordonStephen W Olson

Abstract

Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy. Scleroderma renal crisis (SRC) is one of the most severe complications. Corticosteroid exposure, presence of anti-RNA polymerase III antibodies (ARA), skin thickness, and significant tendon friction rubs are among the known risk factors at SSc diagnosis for developing future SRC. Identification of additional clinical characteristics and laboratory findings could expand and improve the risk profile for future SRC at SSc diagnosis. In this retrospective cohort study of the entire military electronic medical record between 2005 and 2016, we compared the demographics, clinical characteristics, and laboratory results at SSc diagnosis for 31 cases who developed SRC after SSc diagnosis to 322 SSc without SRC disease controls. After adjustment for potential confounding variables, at SSc diagnosis these conditions were all associated with future SRC: proteinuria (p < 0.001; OR 183, 95% CI 19.1-1750), anemia (p = 0.001; OR 9.9, 95% CI 2.7-36.2), hypertension (p < 0.001; OR 13.1, 95% CI 4.7-36.6), chronic kidney disease (p = 0.008; OR 20.7, 95% CI 2.2-190.7), elevated erythrocyte sedimentation rate (p < 0.001; OR 14.3, 95% CI 4.8-43.0), thrombocytopenia (p ...Continue Reading

References

Dec 1, 1978·Annals of Internal Medicine·M T KovalchikJ C Steigerwald
Jan 1, 1977·Contributions to Nephrology·A L Sellers, V J Rosen
May 1, 1984·The American Journal of Medicine·V D SteenG P Rodnan
Oct 18, 2000·Annals of Internal Medicine·V D Steen, T A Medsger
May 20, 2003·Internal Medicine Journal·J G WalkerP J Roberts-Thomson
Dec 4, 2004·Current Opinion in Rheumatology·Eduardo J Cepeda, John D Reveille
Jul 11, 2006·Journal of the American Society of Nephrology : JASN·Dick de ZeeuwRobert H Henning
Mar 29, 2007·European Journal of Endocrinology·Alessandro AntonelliEle Ferrannini
Jun 15, 2007·Annals of the Rheumatic Diseases·L TeixeiraUNKNOWN Group Français de Recherche sur le Sclérodermie (GFRS)
Jul 3, 2007·QJM : Monthly Journal of the Association of Physicians·H PennC P Denton
Jun 6, 2008·Journal of the American Society of Nephrology : JASN·Auke H BrantsmaUNKNOWN PREVEND Study Group
May 8, 2009·The New England Journal of Medicine·Armando GabrielliThomas Krieg
Jun 3, 2009·The Journal of Rheumatology·Veronica CodulloCarlomaurizio Montecucco
Sep 10, 2010·International Journal of Rheumatology·Victoria K Shanmugam, Virginia D Steen
Feb 1, 2011·Arthritis and Rheumatism·Binh NguyenShervin Assassi
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Roland E SchmiederUNKNOWN ONTARGET Investigators
Mar 8, 2012·Arthritis Research & Therapy·Marie HudsonMarvin J Fritzler
Aug 4, 2012·The Journal of Rheumatology·Melissa CaronUNKNOWN Canadian Scleroderma Research Group
Aug 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Franco CozziAndrea Doria
Sep 8, 2012·Current Opinion in Rheumatology·Victoria K Shanmugam, Virginia D Steen
Jan 26, 2013·The Journal of Clinical Endocrinology and Metabolism·M Y RothJ K Amory
Mar 19, 2013·Military Medicine·Kevin A DorranceHarry Fisher
May 23, 2013·QJM : Monthly Journal of the Association of Physicians·H PennC P Denton
Jun 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hassane IzzedineGilbert Deray
Aug 31, 2013·JAMA : the Journal of the American Medical Association·Orlando M GutiérrezUNKNOWN REGARDS Investigators
Nov 2, 2013·Seminars in Arthritis and Rheumatism·Marie HudsonUNKNOWN International Scleroderma Renal Crisis Study Investigators
May 17, 2014·The Journal of Rheumatology·Luc MouthonLoïc Guillevin
Sep 2, 2014·La Presse médicale·Virginia D Steen
Jan 24, 2015·Seminars in Arthritis and Rheumatism·Nilanjana BoseSoumya Chatterjee
Sep 10, 2015·Current Opinion in Rheumatology·Marie Hudson
Feb 19, 2017·Autoimmunity Reviews·Sabrina HoaUNKNOWN Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group Investigators of the Scleroderma Clinical Tria

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Citations

Mar 27, 2019·PloS One·Peter D BurbeloStephen W Olson
Mar 15, 2019·Current Opinion in Rheumatology·Vivek Nagaraja
Jun 21, 2020·Arthritis & Rheumatology·Robert W Simms
Jul 28, 2019·BMC Nephrology·S M GordonS W Olson
Apr 3, 2019·The Journal of Rheumatology·Pia MoinzadehNicolas Hunzelmann
Jan 3, 2019·The Journal of Rheumatology·Veronica Codullo, Carlomaurizio Montecucco
Nov 9, 2019·KI Reports·Marine JacquierMathieu Legendre
Feb 7, 2021·La Presse médicale·Marie HudsonVirginia Steen
Jun 11, 2020·Kidney & Blood Pressure Research·Magdalena ChrabaszczLidia Rudnicka

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